Pharmacokinetics of [14C]-Sarin and Its Changes by Obidoxime and Pralidoxime
Sarin was invented by Schrader in 1937 (6). It was one of the first examples of an organophosphate; it was later stockpiled with other similar compounds (soman, tabun and VX) as nerve gases for warfare. Of all the other 2000 organophosphorus compounds synthesized as insecticides, only several have been used to a major extent in agriculture. For all these compounds their lethal action is based on their blocking of acetylcholinesterase (AChE) (E.C.18.104.22.168), the specific enzyme in cholinergic transmission which destroys acetylcholine. Death occurring by a highly increased concentration of this neurotransmitter, which depolarizes all synaptic connections in brain and the peripheral nervous system, can be prevented by reactivation of the hydrolyzing enzyme, AChE, by limiting or binding the neurotransmitter output, or by protection of the postsynaptic receptors with atropine or similar antagonists.
KeywordsAdrenal Cortex Renal Cortex Organophosphorus Compound Fluoro Phosphate Cardiac Blood
Unable to display preview. Download preview PDF.
- 4.Gotheil, A.M. (1978): Ganztierautoradiographische Untersuchungen uber die Verteilung von Pyridin-2-Aldoxim-[14C]-Methoiodid in Mausen allein und unter Einwirkung von Methylisopropylfluorophosphonat. Dissertation ETH Zurich, Nr. 6220.Google Scholar
- 5.Sammet, R. (1983): Kinetik von [14C]-sarin und deren Beeinflussung durch Obidoxime - eine Ganztierautoradiographische Untersuchung an der Maus. Dissertation ETH Zurich, Nr. 7288.Google Scholar
- 6.Schrader, G. (1952): Monographie Nr. 62, Verlag Chemie, Weinheim.Google Scholar
- 8.Waser, P.G. et al. (in preparation): Investigation on [14C]obidoxime and sarin.Google Scholar