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Acetylcholinesterase and the Maintenance of Neuromuscular Structure and Function

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Dynamics of Cholinergic Function

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 30))

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Abstract

The structural and functional integrity of skeletal muscle depends on the presence and normal function of neuromuscular transmission. Problems may arise from pharmacologic manipulation of neuromuscular transmission and may lead to changes in the development, maintenance, and integrity of the end-plate and muscle fiber. The physiology of neuromuscular transmission can be affected in several ways. The amount of the transmitter acetylcholine (ACh) which is released may be increased or reduced by a wide variety of drugs (2, 6, 7, 11, 28, 29). Post-synaptic sensitivity may be changed by altering either the number of or the affinity of the ACh receptors. Drug induced changes of the input resistance of the muscle fiber membrane can alter the threshold for the generation of muscle action potentials. Variation in one of these factors or in combination with one another can be contributing causes of neuromuscular degeneration (4, 10, 16, 36, 39).

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Authors and Affiliations

  1. Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, 37232, USA

    W-D. Dettbarn

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  1. W-D. Dettbarn
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Editors and Affiliations

  1. Loyola University Stritch School of Medicine, Chicago, Illinois, USA

    Israel Hanin Ph.D.

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© 1986 Plenum Press, New York

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Dettbarn, WD. (1986). Acetylcholinesterase and the Maintenance of Neuromuscular Structure and Function. In: Hanin, I. (eds) Dynamics of Cholinergic Function. Advances in Behavioral Biology, vol 30. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5194-8_69

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  • DOI: https://doi.org/10.1007/978-1-4684-5194-8_69

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5196-2

  • Online ISBN: 978-1-4684-5194-8

  • eBook Packages: Springer Book Archive

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