Relationship between Calcium Entry and ACh Release in K+-Stimulated Rat Brain Synaptosomes

  • J. B. Suszkiw
  • M. E. O’Leary
  • G. P. Toth
Part of the Advances in Behavioral Biology book series (ABBI, volume 30)


The release of acetylcholine (ACh) and other neurotransmitters by potassium depolarization of isolated nerve endings in vitro(synaptosomes) exhibits a rapid temporal decay (1, 3, 6). This could be due either to the depletion of the releasable transmitter pool (4), inactivation of Ca++ entry (7), or a combination of both factors.


Transmitter Release Inactivation Kinetic Phasic Release Tonic Component Releasable Pool 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • J. B. Suszkiw
    • 1
  • M. E. O’Leary
    • 1
  • G. P. Toth
    • 1
  1. 1.Department of PhysiologyUniversity of Cincinnati Medical CenterCincinnatiUSA

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