Effects of Exogenous Choline on Acetylcholine and Choline Contents and Release in Striatal Slices

  • J.-C. Maire
  • J. K. Blusztajn
  • R. J. Wurtman
Part of the Advances in Behavioral Biology book series (ABBI, volume 30)


The synthesis of acetylcholine (ACh) requires choline as the immediate precursor. The free extracellular choline can enter cholinergic neurons through a high affinity and a low affinity transport system (10, 26). ACh content of various tissues has been reported to increase after administration of choline (4, 7, 11, 13, 19), although this effect was not always observed in animal brain in other studies (8, 14, 18, 22). In spite of these discrepancies, results often support the hypothesis that the level of exogenous choline regulate ACh synthesis during periods of increased neuronal demand for the precursor or when choline supply to the neurons is reduced (16, 21, 23).


Stimulation Period Choline Uptake Choline Level Free Choline Choline Content 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • J.-C. Maire
    • 2
  • J. K. Blusztajn
    • 1
  • R. J. Wurtman
    • 1
  1. 1.Department of Nutrition and Food ScienceMassachusetts Institute of TechnologyCambridgeUSA
  2. 2.Departement of PharmacologyCentre Médical UniversitaireGenevaSwitzerland

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