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Biochemical Implications of the Synaptic Vesicle Organization in Quick Frozen Electric Organ Nerve Terminals

  • A. F. Boyne
  • T. E. Phillips
Part of the Advances in Behavioral Biology book series (ABBI, volume 30)

Abstract

The elegant application of the quick freezing technique to neuromuscular junctions by John Heuser and Thomas Reese and their collaborators (8) has put an end to the era of reliance on aldehyde fixations in the correlation of ultrastructure and quantitative details of electrophysiology. We have attempted to apply the same technique to Torpedine electric organ nerve terminals in the hope of resolving some of the biochemical controversies associated with that system (18). This chapter describes recent observations which lead to a re-evaluation of discrepancies in the literature vis-a-vis the vesicle hypothesis. The discussion emphasizes a critical need for information on how the acetylcholine (ACh) balance is affected when synaptic vesicles pump calcium.

Keywords

Synaptic Vesicle Nerve Terminal Basal Lamina Neuromuscular Junction Electric Organ 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • A. F. Boyne
    • 1
    • 2
  • T. E. Phillips
    • 1
    • 2
  1. 1.Department of Pharmacology and Experimental TherapeuticsUniversity of Maryland School of MedicineBaltimoreUSA
  2. 2.Department of PharmacologyNorthwestern University School of MedicineChicagoUSA

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