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Do Motor Neurons Contain Functional Prejunctional Cholinoceptors?

  • G. G. Bierkamper
  • E. Aizenman
  • W. R. Millington
Part of the Advances in Behavioral Biology book series (ABBI, volume 30)

Abstract

Among the many mechanisms which may regulate acetylcholine (ACh) release from mammalian motor nerve terminals is the possibility of negative feedback by the neurotransmitter itself on prejunctional cholinoceptor sites. Autoregulation of neurotransmitter release has been documented in adrenergic systems (21) and in central and autonomic cholinergic systems (12, 15, 22). Negative feedback of released ACh through presynaptic muscarinic receptors has been shown in cerebral cortex (22), hippocampus (15), guinea pig ileum (12), sympathetic ganglion of the bull frog (13) and rat atrium (24).

Keywords

Phrenic Nerve Rest Membrane Potential Motor Nerve Terminal Quantal Content Nicotinic Agonist 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • G. G. Bierkamper
    • 1
  • E. Aizenman
    • 2
  • W. R. Millington
    • 2
  1. 1.Department of PharmacologyUniversity of Nevada School of MedicineRenoUSA
  2. 2.Department of Environmental Health SciencesThe Johns Hopkins UniversityBaltimoreUSA

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