Characterization of [3H]-Nicotine Binding in Rodent Brain and Comparison with the Binding of Other Labelled Nicotinic Ligands
Nicotine can induce diverse pharmacological effects on the central nervous system (CNS), including alterations of spontaneous motoric activity, behavior and memory, antinociceptive effects, hypothermia, antidiuresis and convulsions (11, 15, 23). It is also considered to be a dependence-producing drug (4) and it is widely assumed that the nicotine content of tobacco smoke may play an important role in the development of the tobacco smoking habit (3, 5). Although it is usually assumed that at least some of these effects of nicotine are mediated by nicotinic receptors on neurons in the CNS, there is today no direct evidence for this assumption. It is of interest to note, however, that in some recent experimental studies a change in nicotine-like binding sites in the brain has been observed following chronic administration of nicotine (8, 26).
KeywordsNicotinic Receptor Brain Homogenate Scatchard Plot Rodent Brain Mouse Hippocampus
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