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Identification of Putative M1 Muscarinic Receptors Using [3H]Pirenzepine: Characterization of Binding and Autoradiographic Localization in Human Stellate Ganglia

  • M. Watson
  • W. R. Roeske
  • T. W. Vickroy
  • K. Akiyama
  • J. K. Wamsley
  • P. C. Johnson
  • H. I. Yamamura
Part of the Advances in Behavioral Biology book series (ABBI, volume 30)

Abstract

The advent of selective antimuscarinic drugs such as pirenzepine has led to increased acceptance of the concept of distinct subclasses of muscarinic recegtors. This chapter focuses upon our studies of [3H]pirenzepine ([3H]PZ), which we suggested is an effective ligand for the investigation of putative M1 receptor- effector mechanisms (26–31). Data indicating that [3H]PZ labels putative M1 muscarinic receptors with high affinity is discussed in relation to the growing body of evidence which supports the M1/M2 hypothesis. Emphasis is placed upon our studies of human stellate ganglia. Several relevant reviews have recently appeared in the literature (3, 22, 23, 29).

Keywords

Muscarinic Receptor Lower Esophageal Sphincter Agonist Binding Muscarinic Receptor Subtype Affinity State 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • M. Watson
    • 1
  • W. R. Roeske
    • 1
  • T. W. Vickroy
    • 1
  • K. Akiyama
    • 1
  • J. K. Wamsley
    • 2
  • P. C. Johnson
    • 1
  • H. I. Yamamura
    • 1
  1. 1.Departments of Pharmacology, Biochemistry, Psychiatry, Pathology, Internal Medicine, and the Arizona Research LaboratoriesUniversity of Arizona Health Sciences CenterTucsonUSA
  2. 2.Departments of Psychiatry, Anatomy, and PharmacologyUniversity of Utah School of MedicineSalt Lake CityUSA

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