Interactions of Alaproclate, a Selective 5HT-Uptake Blocker, with Muscarinic Receptors: In Vivo and In Vitro Studies
Cholinergic mechanisms play an important role in higher brain functions such as learning and memory (6). It is hoped that drugs which improve cholinergic transmission would be therapeutically effective in e.g. senile dementia (1, 6). The search for such drugs has led to introduction of precursor: choline (or lecithin) (cf. 1) therapy; to the testing of directly acting cholinergic agonists such as arecoline; or to the use of the acetylcholinesterase inhibitor physostigmine (cf. 3, 5). All of these attempts have met only with partial success to date. Thus the search goes on.
KeywordsMuscarinic Receptor Psychoactive Drug Muscarinic Agonist Cholinergic Agonist Cholinergic Mechanism
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- 6.Hingtgen, J.N. and Aprison, M.M. (1976): In Biology of Cholinergic Function (eds) Goldberg, A.M. and Hanin, I., Raven Press, New York, pp. 515–566.Google Scholar
- 7.Koelle, G.B. (1975): In The Pharmacological Basis of Thera-. peutics (eds) Goodman, L.S. and Gillman, A.,MacMillanPublishing Co., New York, pp. 467–476.Google Scholar
- 8.Lindberg, U.H., Thorberg, S.-0., Bengtsson, S., Renyi, A.L., Ross, S.B. and bgren, S. 0. (1978): J. Med. Chem. 21: 448–456.Google Scholar