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Interactions of Alaproclate, a Selective 5HT-Uptake Blocker, with Muscarinic Receptors: In Vivo and In Vitro Studies

  • E. Danielsson
  • A. Undén
  • Ö. Nordström
  • S. O. Ögren
  • T. Bartfai
Part of the Advances in Behavioral Biology book series (ABBI, volume 30)

Abstract

Cholinergic mechanisms play an important role in higher brain functions such as learning and memory (6). It is hoped that drugs which improve cholinergic transmission would be therapeutically effective in e.g. senile dementia (1, 6). The search for such drugs has led to introduction of precursor: choline (or lecithin) (cf. 1) therapy; to the testing of directly acting cholinergic agonists such as arecoline; or to the use of the acetylcholinesterase inhibitor physostigmine (cf. 3, 5). All of these attempts have met only with partial success to date. Thus the search goes on.

Keywords

Muscarinic Receptor Psychoactive Drug Muscarinic Agonist Cholinergic Agonist Cholinergic Mechanism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • E. Danielsson
    • 1
  • A. Undén
    • 1
  • Ö. Nordström
    • 1
  • S. O. Ögren
    • 2
  • T. Bartfai
    • 1
  1. 1.Department of BiochemistryArrhenius LaboratoryStockholmSweden
  2. 2.Department of PharmacologyAstra Läkemedel ABSödertaljeSweden

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