Cholinergic Rem Sleep Induction Response as a Marker of Endogenous Depression

  • D. Jones
  • S. Kelwala
  • S. Dube
  • E. Jackson
  • N. Sitaram
Part of the Advances in Behavioral Biology book series (ABBI, volume 30)


At the present time the diagnosis of mental disorders is defined by operational criteria, which are primarily based on the presenting sysmptoms, i.e., Research Diagnostic Criteria (RDC) (18); Diagnostic and Statistics Manual III (2). This is also true for treatment decisions and prognosis. There is, however, a growing body of evidence that specific biological abnormalities that have both pathophysiological as well as diagnostic significance may be present, in disorders such as manic depressive illness.


Major Depressive Disorder Discriminant Function Analysis Research Diagnostic Criterion Endogenous Depression Research Diagnostic Criterion 


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  1. 1.
    Aikiskal, H.S. (1980): J. Clin. Psychiatry 41: 6–14.Google Scholar
  2. 2.
    American Psychiatric Association (1980): Diagnostic and Statistical Manual of Mental Disorders. 3rd Ed.Google Scholar
  3. 3.
    Bell, J., Lycaki, H., Jones, D., Kelwala, S. and Sitaram, N. (1983): Psychiatry Research 9: 115–123.CrossRefGoogle Scholar
  4. 4.
    Carroll, B.J., Feinberg, M., Greden, J.F., Tarika, J., Albala, A.A., Haskett, R.F., James, N. M., Kronfol, Z., Lohr, N., Steiner, M., de Vigne, J.P. and Young, E. (1981): Arch. Gen. Psychiatry 38: 15–22.CrossRefGoogle Scholar
  5. 5.
    Endicott, J. and Spitzer, R.L. (1978): Arch. Gen. Psychiatry 35: 837–843.CrossRefGoogle Scholar
  6. 6.
    Feinberg, M., Gillin, J.C., Carroll, B.J., Greden, J.F. and Zis, A.P. (1982): Biol. Psychiatry 17: 327–341.Google Scholar
  7. 7.
    Gillin, J.C., Mendelson, W.B., Sitaram, N. and Wyatt, R.J. (1978): Ann. Rev. Pharmacol. Toxicol. 18: 563–569.CrossRefGoogle Scholar
  8. 8.
    Gillin, J.C., Duncan, W.C., Pettigrew, K., Frankel, B.L. and Snyder, F. (1979): Arch. Gen. Psychiatry 36: 85–90.CrossRefGoogle Scholar
  9. 9.
    Hobson, J.A., McCarley, R.W., McKenna, T.M. (1976): Prog. Neurobiol. 6: 280–376.Google Scholar
  10. 10.
    Hull, C.H. and Nie, N.G. (1979): SPSS Update. New Procedures and Facilities for Releases 7 and 8. New York: McGraw-Hill.Google Scholar
  11. 11.
    Karczmar, A.G., Longo, V.G., Scott de Carolis (1970): Physiol. Behay. 5: 175–182.CrossRefGoogle Scholar
  12. 12.
    Kupfer, D.J., Foster, F.G., Coble, P., McPartland, R. and Ulrich, R. (1978): Am. J. Psychiatry 135: 69–74.Google Scholar
  13. 13.
    Rechtchaffen, A. and Kales, A. (1968): A Manual of Standard Techniques and Scoring System for Sleep States of Human Subjects. NIH Publication #204, U.S. Govt. Printing Office, Washington, D.C.Google Scholar
  14. 14.
    Rush, A.J., Giles, G.E., Roffworg, H.P. and Parker, C.R. (1982): Biol. Psychiatry 17: 327–341.Google Scholar
  15. 15.
    Sitaram, N. and Gillin, J.C. (1980): Biol. Psychiatry 15: 925–955.Google Scholar
  16. 16.
    Sitaram, N., Nurnberger, J.I., Gershon, E.S. and Gillin, J.C. (1980): Science 208: 200–202.CrossRefGoogle Scholar
  17. 17.
    Sitaram, N., Nurnberger, J.I., Gershon, E.S. and Gillin, J.C. (1982): Am. J. Psychiatry 139: 571–576.Google Scholar
  18. 18.
    Spitzer, R.L., Endicott, J. and Robins, E. (1978): Research Diagnostic Criteria for a selected group of functional disorders. d. 3 New York: Biometrics Research Division, New York State Psychiatric Institute.Google Scholar
  19. 19.
    Vogel, G.W., Vogel, F., McAbee, R.S. and Thurmond, A.J. (1980): Arch. Gen. Psychiatry 17: 305–316.Google Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • D. Jones
    • 1
  • S. Kelwala
    • 1
  • S. Dube
    • 1
  • E. Jackson
    • 1
  • N. Sitaram
    • 1
  1. 1.Lafayette ClinicWayne State UniversityDetroitUSA

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