Membrane Transport of Choline by the Human Erythrocyte: Relationship to Intracellular Choline Content, and Effect of Treatment with Lithium

  • A. G. Mallinger
  • U. Kopp
  • J. Mallinger
  • R. L. Stumpf
  • C. Erstling
  • I. Hanin
Part of the Advances in Behavioral Biology book series (ABBI, volume 30)


Choline (Ch) is the metabolic precursor of acetylcholine, and therefore may have an important role in brain function. Because there are a number of similarities in Ch handling between brain synaptosomes and erythrocytes (RBCs) (23), some investigators have felt that the RBC might potentially serve as a model for neuronal Ch transport. Thus, the Ch content of RBCs has been studied in a variety of psychiatric and neurologic conditions, including major depression (10), acute mania (13, 16, 24), Gilles de la Tourette syndrome (3, 9), and dementia (2, 4).


Cord Blood Maternal Blood Bipolar Patient Lithium Treatment Bipolar Affective Disorder 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • A. G. Mallinger
    • 1
  • U. Kopp
    • 1
  • J. Mallinger
    • 1
  • R. L. Stumpf
    • 1
  • C. Erstling
    • 1
  • I. Hanin
    • 1
  1. 1.Western Psychiatric Institute and ClinicUniversity of Pittsburgh School of MedicinePittsburghUSA

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