Cholinergic Receptor Binding in the Frontal Cortex of Suicide Victims
A number of studies using a variety of experimental approaches have suggested that changes in the cholinergic system may be related to affective disorders. Patients with a diagnosis of affective disorder are reported to have increased sensitivity to cholinergic agonists as measured by changes in REM sleep latency (18). Physostigmine reduces the manic symptoms of manic-depressives and exacerbates the symptoms of depression in depressives (9, 10). Additionally, there have been reports that physostigmine induces depressive symptoms in normals (16). The latter observation is also consistent with reports that exposure to organophosphate insecticides (irreversible cholinesterase inhibitors) is associated with depressive symptoms (8). More recently increases in the density of muscarinic cholinergic receptors in skin fibroblasts of manic-depressive patients has been reported (14). In sum, these findings are suggestive of an increased sensitivity in the cholinergic systems of individuals with an affective disorder (as well as the introduction de novo of depressive symptoms in normals).
KeywordsDepressive Symptom Frontal Cortex Affective Disorder Cholinergic System Cholinergic Receptor
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