Cholinergic Receptor Binding in the Frontal Cortex of Suicide Victims

  • M. Stanley
Part of the Advances in Behavioral Biology book series (ABBI, volume 30)


A number of studies using a variety of experimental approaches have suggested that changes in the cholinergic system may be related to affective disorders. Patients with a diagnosis of affective disorder are reported to have increased sensitivity to cholinergic agonists as measured by changes in REM sleep latency (18). Physostigmine reduces the manic symptoms of manic-depressives and exacerbates the symptoms of depression in depressives (9, 10). Additionally, there have been reports that physostigmine induces depressive symptoms in normals (16). The latter observation is also consistent with reports that exposure to organophosphate insecticides (irreversible cholinesterase inhibitors) is associated with depressive symptoms (8). More recently increases in the density of muscarinic cholinergic receptors in skin fibroblasts of manic-depressive patients has been reported (14). In sum, these findings are suggestive of an increased sensitivity in the cholinergic systems of individuals with an affective disorder (as well as the introduction de novo of depressive symptoms in normals).


Depressive Symptom Frontal Cortex Affective Disorder Cholinergic System Cholinergic Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Barraclough, B., Bunch, J., Nelson, B. and Sainsbury, P. (1974): Brit. J. Psychiat. 125: 355–373.CrossRefGoogle Scholar
  2. 2.
    Brunello, N., Chang, D.M. and Costa, E. (1982): Science 215: 1112–1115.CrossRefGoogle Scholar
  3. 3.
    Creese, I., Burt, D.R. and Snyder, S.H. (1977): Science 197: 596–598.CrossRefGoogle Scholar
  4. 4.
    Davies, P. (1979): Brain Res. 171: 319–327.CrossRefGoogle Scholar
  5. 5.
    Davies, P. and Verth, A.H. (1978): Brain Res. 138: 385–392.CrossRefGoogle Scholar
  6. 6.
    Dorpat, T.L. and Ripley, H.S. (1960): Compr. Psychiatry 1: 349–359.CrossRefGoogle Scholar
  7. 7.
    Fisher, A., Mantione, C.R., Abraham, D.J. and Hanin, I. (1982): J. Pharmacol. Exp. Ther. 222: 140–145.Google Scholar
  8. 8.
    Gershon, S. and Shaw, F.H. (1961): Lancet II: 1371–1374.CrossRefGoogle Scholar
  9. 9.
    Janowsky, D.S., El-Yousef, M., Davis, J.M. and Seherke, H.J. (1973): Arch. Gen. Psychiat. 28: 542–547.CrossRefGoogle Scholar
  10. 10.
    Janowsky, D.S., Judd, L.L. and Groom, G. (1982): Proceedings of the 13th Collegium Internationale Neuropsychopharmacologicum Congress, Jerusalem, Israel.Google Scholar
  11. 11.
    Kaufman, C.A., Gillin, J.C., Hill, B., O’Laughlin, T., Phillips, I., Kleinman, J.E. and Wyatt, R.J. (1983): New Research Abst. #66, Amer. Psychiat. Assn., New York.Google Scholar
  12. 12.
    Lerer, B., Stanley, M., Demetriou, S. and Gershon, S. (1983): J. Neurochm. 41: 1680–1683.CrossRefGoogle Scholar
  13. 13.
    Meyerson, L.R., Wennogle, L.P., Abel, M.S., Coupet, J., Lippa, A.S., Rauh, C.E. and Beer, B. (1982): Pharmacol. Biochem. and Behay. 17: 159–163.CrossRefGoogle Scholar
  14. 14.
    Nadi, N.S., Nurnberger, J.I. and Gershon, E.S. (1982): Abstract, Amer. Coll. of Neuropsychopharmacol., p. 14.Google Scholar
  15. 15.
    Perry, E.K., Perry, R.H. and Tomlinson, B.E. (1977): Neurosc. Lett. 4: 185–189.CrossRefGoogle Scholar
  16. 16.
    Risch, S.C., Cohen, P.M., Janowsky, D.S., Kalin, N.H. and Murphy, D.L. (1981): J. Psychiat. Res. 4: 89–94.CrossRefGoogle Scholar
  17. 17.
    Robins, E., Murphy, G.E., Wilkinson, R.H., Gassner, S. and Kayes, J. (1959): Am. J. Public Health 49: 888–899.CrossRefGoogle Scholar
  18. 18.
    Sitaram, N., Nurnberger, J.I., Gershon, E.S. and Gillin, J.C. (1980): Science 208: 200–202.CrossRefGoogle Scholar
  19. 19.
    Wastek, G.H. and Yamamura, H.I. (1978): Mol. Pharmacol. 14: 768–780.Google Scholar
  20. 20.
    Whitehouse, P.J., Price, D.L., Struble, R.G., Clark, A.W., Coyle, J.T. and Delon, M.R. (1982): Science 215: 1237–1239.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • M. Stanley
    • 1
    • 2
  1. 1.Departments of Psychiatry and PharmacologyWayne State University School of MedicineDetroitUSA
  2. 2.Division of PharmacologyLaFayette ClinicDetroitUSA

Personalised recommendations