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Muscarinic Supersensitivity of Anterior Pituitary Acth and β-Endorphin Release in Major Depressive Illness

  • S. C. Risch
  • D. S. Janowsky
  • J. C. Gillin
Part of the Advances in Behavioral Biology book series (ABBI, volume 30)

Abstract

Studies from a number of centers have suggested that there may be an “up-regulation” or supersensitivity of muscarinic cholinergic receptor function in major depressive illness. We have previously demonstrated that major affective disorder patients may be behaviorally supersensitive to the dysphoric-inhibitory effects of centrally active cholinesterase inhibitors (18). In addition, Sitaram, Gillin and co-workers (22) have reported that early rapid eye movement (REM) latency, a major biological marker for depressive illness, may reflect muscarinic supersensitivity of the REM axis in sleep. Janowsky and co-workers (10) have recently reported that affective disorder patients may also have an increased sensitivity to the cardiovascular effects of centrally active cholinergic agents. Finally, Nadi and co-workers (13) have recently reported an increased number of muscarinic receptors on fibroblasts in patients with major depressive illness, which may possibly be a genetically transferrable trait marker for depressive illness. Consequently, a number of investigations have implicated muscarinic supersentitivity in major depressive illness.

Keywords

Cortisol Concentration Schizoaffective Disorder Plasma ACTH Depressive Illness Research Diagnostic Criterion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • S. C. Risch
    • 1
  • D. S. Janowsky
    • 1
  • J. C. Gillin
    • 1
  1. 1.Department of Psychiatry, M-003University of California, San DiegoLa JollaUSA

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