Muscarinic Supersensitivity of Anterior Pituitary Acth and β-Endorphin Release in Major Depressive Illness
Studies from a number of centers have suggested that there may be an “up-regulation” or supersensitivity of muscarinic cholinergic receptor function in major depressive illness. We have previously demonstrated that major affective disorder patients may be behaviorally supersensitive to the dysphoric-inhibitory effects of centrally active cholinesterase inhibitors (18). In addition, Sitaram, Gillin and co-workers (22) have reported that early rapid eye movement (REM) latency, a major biological marker for depressive illness, may reflect muscarinic supersensitivity of the REM axis in sleep. Janowsky and co-workers (10) have recently reported that affective disorder patients may also have an increased sensitivity to the cardiovascular effects of centrally active cholinergic agents. Finally, Nadi and co-workers (13) have recently reported an increased number of muscarinic receptors on fibroblasts in patients with major depressive illness, which may possibly be a genetically transferrable trait marker for depressive illness. Consequently, a number of investigations have implicated muscarinic supersentitivity in major depressive illness.
KeywordsCortisol Concentration Schizoaffective Disorder Plasma ACTH Depressive Illness Research Diagnostic Criterion
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- 2.Bradbury, M.W.B., Burden, J., Hillhouse, E. W. and Jones, M. T. (1974): J. Phyisol. Lond. 239: 269–283.Google Scholar
- 4.Davis, B.M. and Davis, K.L. (1980): Biol. Psychiat. 15: 303–310.Google Scholar
- 6.Endroczi, E., Schreiberg, G. and Lissak, V. (1963): Acta Physiol. Hung. 24: 211–221.Google Scholar
- 9.Janowsky, D.S., Risch, S.C., Parker, D., Huey, L.Y. and Judd, L. (1980): Psychopharmacology Bull. 16: 29–31.Google Scholar
- 10.Janowsky, D.S., Risch, S.C., Huey, L.Y., Judd, L.L. and Rausch, J.L. (1982): Physostigmine-Induced Cardiovascular Changes. Behavioral and Neuroendocrine Correlations. Presented at the Annual Meeting of the American College of Neuropsychopharmacology, San Juan, Puerto Rico.Google Scholar
- 11.Krieger, H.P. and Krieger, D.T. (1970): Am. J. Physiol. 218: 1632–1641.Google Scholar
- 13.Nadi, N.S., Nurnberger,J.I. and Gershon,E.S. (1982): Presented at the Annual Meeting of the American College of Neuropsychopharmacology. San Juan, Puerto Rico.Google Scholar
- 19.Risch, S.C. (1982): Biological Psychiatry 17 (10): 1071–1080.Google Scholar