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Cortical Cholinergic Innervation: Distribution and Source in Monkeys

  • R. G. Struble
  • J. Lehmann
  • S. J. Mitchell
  • L. C. Cork
  • J. T. Coyle
  • D. L. Price
  • M. R. Delong
  • P. G. Antuono
Part of the Advances in Behavioral Biology book series (ABBI, volume 30)

Abstract

Cholinergic neurons of the primate basal forebrain, termed the Chl-4 system (18), can be identified by their chromophilia, intensity with which they stain for acetylcholinesterase (AChE) activity, and content of choline acetyltransferase (ChAT)-like immunoreactivity (10, 13, 18, 20). These cholinergic nerve cells are located in the medial septal nucleus (Chl), nucleus of the diagonal band of Broca (dbB) (Ch2), nucleus basalis of Meynert (nbM) (Ch4), and in laminae around the globuspallidus. Anterograde and retrograde transport studies in primates (e.g., 12, 18, 21, 27) and combined tracing and AChE histochemistry (17) show that these neurons project directly to cortex, and suggest that neurons in Chl, Ch2, and Ch4 provide the major source of cholinergic innervation of the amygdala, hippocampus, and neocortex.

Keywords

Globus Pallidus Basal Forebrain Cynomolgus Monkey Glutamic Acid Decarboxylase ChAT Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • R. G. Struble
    • 1
  • J. Lehmann
    • 2
  • S. J. Mitchell
    • 3
  • L. C. Cork
    • 4
  • J. T. Coyle
    • 5
  • D. L. Price
    • 6
  • M. R. Delong
    • 7
  • P. G. Antuono
    • 2
  1. 1.Neuropathology Laboratory, Department of PathologyThe Johns Hopkins University School of MedicineBaltimoreUSA
  2. 2.Department of Psychiatry and Behavioral SciencesThe Johns Hopkins University School of MedicineBaltimoreUSA
  3. 3.Department of NeurologyThe Johns Hopkins University School of MedicineBaltimoreUSA
  4. 4.Division of Comparative Medicine, Neuropathology Laboratory, and Department of PathologyThe Johns Hopkins University School of MedicineBaltimoreUSA
  5. 5.Departments of Neuroscience, Pediatrics, Pharmacology and Experimental Therapeutics, and Psychiatry and Behavioral SciencesThe Johns Hopkins University School of MedicineBaltimoreUSA
  6. 6.Neuropathology Laboratory, Departments of Pathology, Neurology and NeuroscienceThe Johns Hopkins University School of MedicineBaltimoreUSA
  7. 7.Departments of Neurology and NeuroscienceThe Johns Hopkins University School of MedicineBaltimoreUSA

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