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Dynamics of Cholinergic Function pp 261–271Cite as

Determinants of Acetylcholine Levels in Aged Rats

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Part of the book series: Advances in Behavioral Biology ((ABBI,volume 30))

Abstract

Aged rats exhibit altered capabilities to sustain synaptic transmission at the diaphragm neuromuscular junction. For example, synaptic depression is enhanced in older animals (15). Moreover, there are associated changes in end-plate structure. In senescent animals, there are more nerve terminal branches and less sprouting and degeneration per end plate (17; cf. 4). In addition, the number of synaptic vesicles per terminal increases with age (17).

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Author information

Authors and Affiliations

  1. Department of Physiology, University of Wisconsin, Madison, Wisconsin, 53706, USA

    D. O. Smith

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  1. D. O. Smith
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Editor information

Editors and Affiliations

  1. Loyola University Stritch School of Medicine, Chicago, Illinois, USA

    Israel Hanin Ph.D.

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© 1986 Plenum Press, New York

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Smith, D.O. (1986). Determinants of Acetylcholine Levels in Aged Rats. In: Hanin, I. (eds) Dynamics of Cholinergic Function. Advances in Behavioral Biology, vol 30. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5194-8_24

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  • DOI: https://doi.org/10.1007/978-1-4684-5194-8_24

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5196-2

  • Online ISBN: 978-1-4684-5194-8

  • eBook Packages: Springer Book Archive

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