Sympathetic Ingrowth: A Result of Cholinergic Nerve Injury in the Adult Mammalian Brain
The brain is capable of dramatic and vigorous responses to injury. We have been studying one such rearrangement, sympathetic ingrowth, which takes place in the adult rat brain after injury to certain central cholinergic pathways. The purpose of this chapter is to describe sympathetic ingrowth, its regulation and function. Although sympathetic ingrowth appears to be an unusual and perhaps anomalous form of neuronal plasticity, its study has led to a better understanding of the molecular mechanisms that probably underlie the regulation of other neuronal rearrangements. The ability to regulate neuronal rearrangements such as sympathetic ingrowth is likely to lead to the development of pharmacological agents that may be useful to patients with brain injury, stroke or dementia.
KeywordsNerve Growth Factor Hippocampal Formation Mossy Fiber Superior Cervical Ganglion Septal Lesion
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