Basal Forebrain Cholinergic Systems in Primate Brain: Anatomical Organization and Role in the Pathology of Aging and Dementia

  • D. L. Price
  • C. A. Kitt
  • J. C. Hedreen
  • P. J. Whitehouse
  • R. G. Struble
  • L. C. Cork
  • L. C. Walker
  • W. C. Mobley
  • G. D. Crawford
  • P. M. Salvaterra
  • B. H. Wainer
Part of the Advances in Behavioral Biology book series (ABBI, volume 30)

Abstract

Over the past several years, there have been substantial advances in our understanding of cholinergic systems in the primate central nervous system. Cholinergic neurons in the medial septum, diagonal band of Broca (dbB), and nucleus basalis of Meynert (nbM) provide the major cholinergic innervation to the amygdala, hippocampus, and neocortex. These cholinergic cell groups, recently termed the Chl-4 system (26), are affected in Alzheimer’s disease (AD) and related disorders. In this review, we first discuss: the anatomical organization of the Chl-4 system; evidence implicating this system in the pathology of AD and related disorders; and hypothetical models by which dysfunction and, eventually, death of these cells may account for some of the neurochemical/neuropathological changes observed in the brains of individuals with AD and related dementias.

Keywords

Dementia Polypeptide Neurol Fibril Choline 

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • D. L. Price
    • 1
  • C. A. Kitt
    • 1
  • J. C. Hedreen
    • 1
  • P. J. Whitehouse
    • 1
  • R. G. Struble
    • 1
  • L. C. Cork
    • 1
  • L. C. Walker
    • 1
  • W. C. Mobley
    • 1
  • G. D. Crawford
    • 2
  • P. M. Salvaterra
    • 2
  • B. H. Wainer
    • 3
  1. 1.Neuropathology LaboratoryThe Johns Hopkins University School of MedicineBaltimoreUSA
  2. 2.Division of NeuroscienceCity of Hope Research InstituteDuarteUSA
  3. 3.Department of PathologyUniversity of ChicagoChicagoUSA

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