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Cholinergic Neurons and Cholinergic Projections in the Mammalian CNS

  • P. L. McGeer
  • E. G. McGeer
  • H. Kimura
  • J.-F. Peng
Part of the Advances in Behavioral Biology book series (ABBI, volume 30)

Abstract

Considerable information regarding the distribution of cholinergic neurons in the mammalian central nervous system has now been accumulated. This is due to the development of reliable markers for these cells. The most significant one is immunohistochemical staining for choline acetyltransferase (ChAT), the enzyme for acetylcholine synthesis. Many laboratories have now produced antibodies to ChAT from various sources (13, 14, 17, 18, 19, 37, 47, 58, 66, 69, 70). They are of two general kinds: polyclonal, from the serum of mammals immunized against enzyme purified from various ChAT-rich sources, and monoclonal, raised by the hybridoma technique using mouse myeloma cell lines. Two important ancillary techniques are histochemistry for acetylcholinesterase (AChE), particularly after diisopropylfluorophosphate (DFP) administration, and retrograde choline transport. The former method is based on the observation that many known cholinergic cells have higher levels of AChE than cholinoceptive cells and this difference can be revealed by the re-synthesis rate of AChE following administration of an irreversible inhibitor such as DFP. The retrograde choline transport technique is based upon the high affinity uptake system for choline characteristic of cholinergic nerve terminals.

Keywords

Cholinergic Neuron Reticular Formation Diagonal Band Cholinergic Cell Cholinergic Pathway 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Albanese, A. and Butcher, L.L. (1979): Neurosci. Lett. 14: 101–104CrossRefGoogle Scholar
  2. 2.
    Armstrong, D.M., Saper, C.B., Levey, A.I., Wainer, B.H. and Terry, R.D. (1982): Soc. Neurosci. Abstrs. 8: 662.Google Scholar
  3. 3.
    Armstrong, D.M., Saper, C.B., Levey, A.I., Wainer, B.H. and Terry, R.D. (1983): J. Comp. Neurol. 216: 53–68.CrossRefGoogle Scholar
  4. 4.
    Basbaum, A.I., Clanton, C.H. and Fields, H.L. (1978): J. Comp. Neurol. 178: 209–224.CrossRefGoogle Scholar
  5. 5.
    Beckstead, R.M., Domesick, V.B. and Nauta; W.J.H. (1979): Brain Res. 175: 191–217.CrossRefGoogle Scholar
  6. 6.
    Bigl, V., Woolf, N.J. and Butcher, L.L. (1982): Brain Res. Bull. 8: 727–729.CrossRefGoogle Scholar
  7. 7.
    Butcher, L.L. and Marchand, R. (1978): Eur. J. Pharmacol. 52: 415–417.CrossRefGoogle Scholar
  8. 8.
    Butcher, L.L., Talbot, K. and Bilezikjian, L. (1975): J. Neural. Transm. 37: 127–153.CrossRefGoogle Scholar
  9. 9.
    Chao, L.P., Kan, K.J.K. and Hung, F.-M. (1982): Brain Res. 235: 65–82.CrossRefGoogle Scholar
  10. 10.
    Carpenter, M.B. and Sutin, J. (1983): Human Neuroanatomy, 8th edition, Williams and Wilkins, Baltimore, pp. 291, 296, 334, 372.Google Scholar
  11. 11.
    Contestible, A. and Fonnum, F. (1983): Brain Res. 275: 287–297.CrossRefGoogle Scholar
  12. 12.
    Coyle, J.T., Molliver, M.E. and Kuhar, M.J. (1978): J. Comp. Neurol. 180: 301–324.CrossRefGoogle Scholar
  13. 13.
    Cozzari, C. and Hartman, B.K. (1977): Proc. Intl. Soc. Neurochem. 6: 140.Google Scholar
  14. 14.
    Dietz, G.W. Jr. and Salvaterra, P.M. (1980): J. Biol. Chem. 255: 10612–10617.Google Scholar
  15. 15.
    Divac, I. (1975): Brain Res. 9: 385–398.CrossRefGoogle Scholar
  16. 16.
    Eckenstein, F. and Thoenen, H. (1983): Neurosci. Lett. 36: 211–215.CrossRefGoogle Scholar
  17. 17.
    Eckenstein, F. and Thoenen, H. (1982): The EMBR Journal 1: 363–368.Google Scholar
  18. 18.
    Eng, L.F., Uyeda, C.T., Chao, L.P. and Wolfgram, F. (1974): Nature 250: 243–245.CrossRefGoogle Scholar
  19. 19.
    Fex, J., Altschuler, R.A., Parakkal, M.H. and Eckenstein, F. (1982): Soc. Neurosci. Abstrs. 8: 41.Google Scholar
  20. 20.
    Fonnum, F. (1970): J. Neurochem. 17: 1029–1037.CrossRefGoogle Scholar
  21. 21.
    Gottesfeld, Z. and Jacobowitz, D.M. (1978): Brain Res. 156: 329–332.CrossRefGoogle Scholar
  22. 22.
    Gottesfeld, Z. and Jacobowitz, D.M. (1979): Brain Res. 176: 391–394.CrossRefGoogle Scholar
  23. 23.
    Hattori, T., McGeer, E.G., Singh, V.K. and McGeer, P.L. (1977): Exp. Neurol. 55: 666–679.CrossRefGoogle Scholar
  24. 24.
    Houser, C.R., Crawford, G.D., Barber, R.P., Salvaterra, P.M. and Vaughn, J.E. (1983): Brain Res. 266: 97–119.CrossRefGoogle Scholar
  25. 25.
    Houser, C.R., Crawford, G.D., Salvaterra, P.M. and Vaughn, J.E. (1983): Soc. Neurosci. Abstrs. 9: 576.Google Scholar
  26. 26.
    Johnston, M.V. and Coyle, J.T. (1979): Brain Res. 170: 135–155.CrossRefGoogle Scholar
  27. 27.
    Jones, E.G., Burton, H., Saper, C.B. and Swanson, L.W. (1976): J. Comp. Neurol. 167: 385–420.CrossRefGoogle Scholar
  28. 28.
    Katoka, K., Nakamura, Y. and Hassler, R. (1973): Brain Res. 62: 264–267.CrossRefGoogle Scholar
  29. 29.
    Kemp, J.M. and Powell, T.P.S. (1971): Phil. Trans. B. 262: 383–401.CrossRefGoogle Scholar
  30. 30.
    Kievet, J. and Kuypers, H.G.J. (1975): Science 187: 660–662.CrossRefGoogle Scholar
  31. 31.
    Kimura, H., McGeer, E.G., Peng, F. and McGeer, P.L. (1983): In: Structure and Function of peptidergic and Aminergic Neurons, (eds) Y. Sano, Y. Ibata and E.Z. Zimmerman. Japan Scientific Societies Press, Tokyo, pp. 26, 274.Google Scholar
  32. 32.
    Kimura, H., McGeer, P.L., Peng, J.H. and McGeer, E.G. (1981): J. Comp. Neurol. 200: 151–201.CrossRefGoogle Scholar
  33. 33.
    Kimura, H., McGeer, P.L. and Peng, J.H. (1984): In: Handbook of Chemical Neuroanatomy, (eds) A. Bjorklund and T. Hokfelt. (eds) Elsevier/North Holland Biomedical Press B.V.Google Scholar
  34. 34.
    Kimura, H., McGeer, P.L., Peng, J.H. and McGeer, E.G. (1980): Science 208: 1057–1059.CrossRefGoogle Scholar
  35. 35.
    Lehmann, J. and Fibiger, H.C. (1978): J. Neurochem. 30: 615–624.CrossRefGoogle Scholar
  36. 36.
    Lehmann, J.C., Nagy, J.I., Atmadja, S. and Fibiger, H.C. (1980): Neuroscience 5: 1161–1174.CrossRefGoogle Scholar
  37. 37.
    Levey, A.I., Aoki, M., Fitch, F.W. and Wainer, B.H. (1981): Brain Res. 218: 383–387.CrossRefGoogle Scholar
  38. 38.
    McGeer, E.G., McGeer, P.L. and Staines, W.A. (1984): Can. J. Neurol. Sei. 11: 89–99.Google Scholar
  39. 39.
    McGeer, E.G., Wada, J.A., Terao, A. and Jung, E. (1969): Exp. Neurol. 24: 277–284.CrossRefGoogle Scholar
  40. 40.
    McGeer, P.L., Kimura, H., McGeer, E.G. and Peng, J.H. (1982): In: Compartmentation of Cholinergic Systems in the Central Nervous System, (ed) H. Bradford. Plenum Press, N.Y. andLond., pp. 255–289.Google Scholar
  41. 41.
    McGeer, P.L., and McGeer, E.G. (1982): In: Critical Reviews in Toxicology. Vol. 10. (ed) L. Goldberg, CRC Press, Boca Raton, Florida, pp. 1–26.Google Scholar
  42. 42.
    McGeer, P.L. and McGeer, E.G. (1984): In: Handbook of Neuro-chemistry. Vol. 6. (ed) A. Lajtha, Plenum Press, New York, pp. 379–410.Google Scholar
  43. 43.
    McGeer, P.L., McGeer, E.G., Fibiger, H.C. and Wickson, V. (1971): Brain Res. 35: 308–314.CrossRefGoogle Scholar
  44. 44.
    McGeer, P.L., McGeer, E.G., Singh, V.K. and Chase, W.H. (1974): Brain Res. 81: 373–379.CrossRefGoogle Scholar
  45. 45.
    McGeer, P.L., McGeer, E.G., Suzuki, J., Dolman, C.E. and Nagai, T. (1984): Neurology 34: 741–745.CrossRefGoogle Scholar
  46. 46.
    Maley, B., Eide, R., Wainer, B. and Levey, A. (1982): Soc. Neurosci. Abstrs. 8: 518.Google Scholar
  47. 47.
    Malthe-Sorenssen, D., Lea, T., Fonnum, F. and Eskeland, T. (1978): J. Neurochem. 30: 35–46.CrossRefGoogle Scholar
  48. 48.
    Matthews, D.A., Salvaterra, P.M., Crawford, G.D., Houser, C.R. and Vaughn, J.E. (1983): Soc. Neurosci. Abstrs. 9: 79.Google Scholar
  49. 49.
    Meibach, R.C. and Weaver, L.M. (1979): J. Neural Transm. 44: 87–96.CrossRefGoogle Scholar
  50. 50.
    Mesulam, M.M., Mufson, E.J., Levey, A.I. and Wainer, B. H. (1983): J. Comp. Neurol. 214: 170–197.CrossRefGoogle Scholar
  51. 51.
    Mesulam, M.M. and Van Hoesen, G.W. (1976): Brain Res. 109: 152–157.CrossRefGoogle Scholar
  52. 52.
    Mufson, E.J., Levey, A., Wainer, B. and Mesulam, M.M. (1982): Soc. Neurosci. Abstrs. 8: 135.Google Scholar
  53. 53.
    Nagai, T., McGeer, P.L. and McGeer, E.G. (1982): J. Neurosci. 2: 513–520.Google Scholar
  54. 54.
    Nagai, T. McGeer, P.L., Peng, J.H., McGeer, E.G. and Dolman, C.E. (1983): Neurosci. Lett. 36: 195–199.CrossRefGoogle Scholar
  55. 55.
    Nagai, T., Pearson, T., Peng, F., McGeer, E.G. and McGeer, P.L. (1983): Brain Res. 265: 300–306.CrossRefGoogle Scholar
  56. 56.
    Nyberg-Hansen, R. (1964): J. Comp. Neurol. 122: 355–368.CrossRefGoogle Scholar
  57. 57.
    Pare, M.F., Jones, B.E. and Beaudet, A. (1982): Soc. Neurosci. Abstrs. 8: 517.Google Scholar
  58. 58.
    Park, D.H., Ross, M.E., Pickel, V.M., Reis, D.J. and Joh, T.H. (1982): Neurosci. Lett. 34: 129–135.CrossRefGoogle Scholar
  59. 59.
    Pearson, R.C.A., Gatter, K.C., Brodal, P. and Powell, T.P.S. (1983): Brain Res. 259: 132–136.CrossRefGoogle Scholar
  60. 60.
    Peng, J.H., Kimura, H., McGeer, P.L. and McGeer, E.G. (1981): Neurosci. Lett. 21: 281–285.CrossRefGoogle Scholar
  61. 61.
    Peng, J.H., McGeer, P.L., Kimura, H., Sung, S.C. and McGeer, E.G. (1980): Neurochem. Res. 5: 943–961.CrossRefGoogle Scholar
  62. 62.
    Peng, J.H., McGeer, P.L. and McGeer, E.G. (1982): J. Neuroimmunol. 3: 113–121.CrossRefGoogle Scholar
  63. 63.
    Saper, C.B. (1982): Brain Res. 242: 33–40.CrossRefGoogle Scholar
  64. 64.
    Saper, C.B. and Loewy, A.D. (1980): Brain Res. 197: 297–317.CrossRefGoogle Scholar
  65. 65.
    Satoh, K., Armstrong, D.M. and Fibiger, H.C. (1983): Soc. Neurosci. Abstrs. 9: 80.Google Scholar
  66. 66.
    Shuster, L. and O’Toole, C. (1974): Life Sciences 15: 645–656.CrossRefGoogle Scholar
  67. 67.
    Shute, C.C.D. and Lewis, P.R. (1963): Nature 199: 1160–1164.CrossRefGoogle Scholar
  68. 68.
    Shute, C.C.D. and Lewis, P.R. (1967): Brain 90: 497–522.CrossRefGoogle Scholar
  69. 69.
    Singh, V.K. and McGeer, P.L. (1974): Life Sciences 15: 901–913.CrossRefGoogle Scholar
  70. 70.
    Slemmon, J.R., Salvaterra, P.M., Crawford, G.D. and Roberts, E. (1982): J. Biol. Chem. 257: 3847–3852.Google Scholar
  71. 71.
    Sofroniew, M.V., Edkenstein, F., Thoenen, H. and Cuello, A. C. (1982): Neurosci. Lett. 33: 7–12.CrossRefGoogle Scholar
  72. 72.
    Sofroniew, M.V., Eckenstein, F., Thoenen, H. and Cuello, A.C. (1982): Soc. Neurosci. Abstrs. 8: 516.Google Scholar
  73. 73.
    Vincent, S.R., Staines, W.A. and Fibiger, H.C. (1983): Neurosci. Lett. 35: 111–114.CrossRefGoogle Scholar
  74. 74.
    Vincent, S.R., Satoh, K. and Fibiger, H.C. (1983): Soc. Neurosci. Abstrs. 9: 576.Google Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • P. L. McGeer
    • 1
  • E. G. McGeer
    • 1
  • H. Kimura
    • 1
  • J.-F. Peng
    • 1
  1. 1.Kinsmen Laboratory of Neurological ResearchUniversity of British ColumbiaVancouverCanada

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