Relationships between Choline Acetyltransferase and Muscarinic Binding in Aging Rodent Brain and in Alzheimer’s Disease

  • E. D. London
  • S. B. Waller
Part of the Advances in Behavioral Biology book series (ABBI, volume 30)


The literature concerning age effects on cholinergic neurochemical parameters, in the brain presents a heterogeneous picture, both within and among species. Whereas some studies of human postmortem material have demonstrated age-dependent declines in choline acetyltransferase (ChAT) activity in various brain regions (5, 12, 19), others have revealed no ChAT losses in some of the same regions (5, 10, 12, 19, 28). In brain regions from C57BL/6J and A/J mice, we have observed age-dependent increases in ChAT (26); whereas, other studies have revealed no changes or decreases in the brains of C57BL/6J mice (23, 25), other mouse strains (24), and rats (2, 23, 25).


Choline Chloride ChAT Activity Acetyl Coenzyme Postmortem Sample Cholinergic Marker 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • E. D. London
    • 1
    • 2
  • S. B. Waller
    • 2
  1. 1.Addiction Research Center National Institute on Drug Abusec/o Francis Scott Key Medical CenterBaltimoreUSA
  2. 2.Gerontology Research Center, National Institute on Agingc/o Francis Scott Key Medical CenterBaltimoreUSA

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