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Interactions of Calcium Homeostasis, Acetylcholine Metabolism, Behavior and 3,4-Diaminopyridine during Aging

  • G. E. Gibson
  • C. Peterson
Part of the Advances in Behavioral Biology book series (ABBI, volume 30)

Abstract

Normal aging is often associated with a reduction in mental abilities. However, the functions that are altered and the age when they begin to decline is controversial. For example, decreased performance on various aspects of the Wechsler Adult Intelligence Scale (WAIS) occurs at different ages. The full scale WAIS is composed of a verbal scale (6 tests) and a performance scale (5 tests). Although some reductions in the full scale performance are apparent by age 40, the largest decline occurs after the age of 70. The performance tests show greater age-related deficits than the verbal tests (15, 62). The molecular mechanisms that lead to the decline in brain function with aging and their relation to the biochemical basis of the debilitating deficits of Alzheimer’s disease are unknown. The similarities between aging and Alzheimer’s disease are detailed elsewhere (18).

Keywords

Calcium Uptake Brain Slice Calcium Homeostasis Aged Mouse Cholinergic System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • G. E. Gibson
    • 1
  • C. Peterson
    • 1
  1. 1.Department of NeurologyCornell University Medical College Burke Rehabilitation CenterWhite PlainsUSA

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