The Aging of Cholinergic Synapses: Ontogenesis of Cholinergic Receptors

  • A. Nordberg
Part of the Advances in Behavioral Biology book series (ABBI, volume 30)


Cholinergic synapses in brain undergo dynamic changes during development, maturation and aging. During the life span we can assume that there is a continuous interregulation between presynaptic and postsynaptic activity. In recent years several investigators have shown for example that both muscarine- and nicotine-like receptor binding sites in brain can be modulated by a continuous drug treatment (13, 23, 31, 32, 34, 37). Signs for a compensatory “upregulating” mechanism for muscarinic binding sites have been reported in pathological states such as dementia of Alzheimer type (29) and Parkinson’s Disease (35).


Muscarinic Receptor Brain Research Cholinergic Receptor High Affinity Site ChAT Activity 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • A. Nordberg
    • 1
  1. 1.Department of PharmacologyUniversity of UppsalaUppsalaSweden

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