Protection and Therapeutic Effect of CDP Choline in Hypocapnic Neurons in Culture
A low oxygen supply to the nervous tissue induced by hypoxia or anoxia in vitro or by ischemia in vivo is known to produce a severe modification of phospholipid metabolism (2) and to be at the origin of the well known post mortem effect which has hindered for years the correct determination of free choline concentrations in the brain (7). Recently the stimulation of phospholipid metabolism and especially of phosphatidylcholine through the use of its precursors has opened up new ways of understanding the metabolism of nerve cell membranes and, in some instances, to produce new therapeutic approaches for various diseases such as Alzheimer’s disease, senile dementia, or for protection in aging cells (4). The relevance of CDP-choline as a precursor of phosphatidylcholine has been known since the establishment of the essential steps of the Kennedy pathway, and its use in medical and clinical practice has opened up new useful therapeutic treatments. Traumatic cerebral oedemas, cerebral anoxia, local ischemic damages, producing in some cases hemiplegia, can be treated with some success with CDPcholine (14,10).
KeywordsPhospholipid Metabolism Acid Soluble Fraction Neuronal Cell Culture Kennedy Pathway Choline Metabolism
Unable to display preview. Download preview PDF.
- 2.Ansell, G.B. and Spanner, S. In Cholinergic Mechanisms (eds) G. Pepeu and H. Ladinsky, Plenum Press, New York (1981): pp. 393–403.Google Scholar
- 3.Arienti, G., Corazzi, L., Mastrofini, P., Montanini, I., Tirillini, B. and Porcellati, G. (1979): Italian J. Biochem. 28: 39–45.Google Scholar
- 6.Dreyfus, H., Louis, J.C., Harth, S., Durand, M. and Massarelli, R. In Neural Transmission, Learning and Memory (eds) R. Caputto and C. Ajmone Marsan, Raven Press, New York (1983): pp. 21–33.Google Scholar
- 8.Floridi, A., Vecchini, A., Palmerini, C.A., Binaglia, L. and Porcellati, G. (1981): Italian J. Biochem. 30: 317–319.Google Scholar
- 10.Kondo, Y. (1963): Arch. Japan Chir. 32: 489–511.Google Scholar
- 11.Louis, J.C., Dreyfus, H., Wong, T.Y., Vincendon, G. and Massarelli, R. In Neural Transmission, Learning and Memory (eds) R. Caputto and C. Ajmone Marsan, Raven Press, New York (1983): pp. 49–61.Google Scholar
- 12.Massarelli, R., Dainous, F., Freysz, L., Dreyfus, H., Mozzi, R., Floridi, A., Siepi, D. and Porcellati, G. In Basic and Clinical Aspects of Molecular Neurobiology (eds) A.M. Giuffrida Stella, G. Gombos, C. Benzi and H.S. Bachelard Fond. Intern. Menarini (1982): pp. 147–155.Google Scholar
- 14.Tanakamaru, S. (1964): Kumamoto Igaku Zasshi 38: 145–163.Google Scholar