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Clinical Studies of the Cholinergic Deficit in Alzheimer’s Disease

  • C. A. Johns
  • R. C. Mohs
  • E. Hollander
  • B. M. Davis
  • B. S. Greenwald
  • M. Davidson
  • T. B. Horvath
  • K. L. Davis
Part of the Advances in Behavioral Biology book series (ABBI, volume 30)

Abstract

Alzheimer’s disease (AD) is a major mental health problem which will reach epidemic proportions as the percentage of elderly in the population increases. Three to four percent of the population of the United States above age 65 are estimated to be afflicted by this progressive dementia (31, 52), for which at present neither treatment nor definitive antemortem diagnostic tests exist. As current research elucidates the neurochemical and histologic changes that characterize AD, biologic markers useful in diagnosis and rational treatments may be developed.

Keywords

ChAT Activity Recognition Memory Task Replication Phase Dementia Rate Scale Cholinergic Deficit 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • C. A. Johns
    • 1
    • 2
  • R. C. Mohs
    • 1
    • 2
  • E. Hollander
    • 1
    • 2
  • B. M. Davis
    • 1
    • 2
  • B. S. Greenwald
    • 1
    • 2
  • M. Davidson
    • 1
    • 2
  • T. B. Horvath
    • 1
    • 2
  • K. L. Davis
    • 1
    • 2
  1. 1.Department of PsychiatryBronx Veterans Administration Medical CenterBronxUSA
  2. 2.Departments of Psychiatry and PharmacologyMount Sinai School of Medicine of the City University of New YorkNew YorkUSA

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