Skip to main content
SpringerLink
Log in

A New Pharmacological Tool to Study Acetylcholine Storage in Nerve Terminals

  • Chapter
Dynamics of Cholinergic Function

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 30))

Abstract

Synaptic vesicles isolated from the electric organ of Torpedo californica exhibit MgATP stimulated uptake of tritium labelled acetylcholine, [3H]ACh. The process probably is mediated by a proton pumping ATPase which acidifies the interior of the vesicles (7, 8, 17, 18). A hypothesized separate ACh transporter protein in the vesicle membrane appears to utilize the vesicle membrane pH gradient to drive concentrative uptake of exogenous [3H]ACh (1, 15, 16).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Anderson, D.C., King, S. C. and Parsons, S.M. (1982): Biochemistry 21: 3037–3043.

    Article  Google Scholar 

  2. Anderson, D.C., King, S. C. and Parsons, S.M. (1983): Molec. Pharmacol. 24: 55–59.

    Google Scholar 

  3. Anderson, D.C., King, S. C. and Parsons, S.M. (1983): Molec.Pharmacol. 24: 48–54.

    Google Scholar 

  4. Anderson, D.C., Bahr, B.A. and Parsons, S.M. (1985): J. Neurochem., submitted.

    Google Scholar 

  5. Bahr, B.A. and Parsons, S.M. (1985): J. Neurochem., submitted.

    Google Scholar 

  6. Bowman, W.C. and Marshall, I.G. (1972): Internat. Encyclo.Pharmacol. therp., Sec. 141: 377–378.

    Google Scholar 

  7. Breer, H., Morris, S.J. and Whittaker, V.P. (1977): Eur. J. Biochem. 80: 313–318.

    Article  Google Scholar 

  8. Fuldner, H.H. and Stadler, H. (1982): Eur. J. Biochem. 121: 519524.

    Google Scholar 

  9. Isragl, M. and Lesbats, B. (1981): J. Neurochem. 37: 1475–1483.

    Article  Google Scholar 

  10. Marshall, I.G. (1970): Br. J. Pharmacol. 38:503–516.

    Google Scholar 

  11. Marshall, I.G. (1970): Br. J. Pharmacol. 42: 68–77.

    Google Scholar 

  12. Marshall, I.G. and Parsons, R.L. (1975): Br. J. Pharmacol. 54: 333–338.

    Google Scholar 

  13. Michaelson, D.M. and Ophir, I. (1980): J. Neurochem. 34: 1483–1490.

    Google Scholar 

  14. Michaelson, D.M., Pinchasi, I., Angel, I., Ophir, I., Sokolov-sky, M. and Rudnick, G. (1979): In Molecular Mechanisms of Biological Recognition (ed) M. Balaban, Elsevier/Holland, pp. 361–372.

    Google Scholar 

  15. Parsons, S.M., Carpenter, R.S., Koenigsberger, R. and Rothlein, J.E. (1982): Fed. Proc. 41: 2765–2768.

    Google Scholar 

  16. Parsons, S.M. and Koenigsberger, R. (1980): Proc. Nat’l. Acad. Sci. U.S.A. 77: 6234–6238.

    Article  Google Scholar 

  17. Rothlein, J.E. and Parsons, S.M. (1979): Biochem. Biophys. Res. Comm. 88: 1069–1076.

    Article  Google Scholar 

  18. Rothlein, J.E. and Parsons, S.M. (1982): J. Neurochem. 39: 1660–1668.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Chemistry, University of California, Santa Barbara, California, 93106, USA

    S. M. Parsons, D. C. Anderson, B. A. Bahr & G. A. Rogers

Authors
  1. S. M. Parsons
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. C. Anderson
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. B. A. Bahr
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. G. A. Rogers
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Loyola University Stritch School of Medicine, Chicago, Illinois, USA

    Israel Hanin Ph.D.

Rights and permissions

Reprints and permissions

Copyright information

© 1986 Plenum Press, New York

About this chapter

Cite this chapter

Parsons, S.M., Anderson, D.C., Bahr, B.A., Rogers, G.A. (1986). A New Pharmacological Tool to Study Acetylcholine Storage in Nerve Terminals. In: Hanin, I. (eds) Dynamics of Cholinergic Function. Advances in Behavioral Biology, vol 30. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5194-8_117

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-5194-8_117

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5196-2

  • Online ISBN: 978-1-4684-5194-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation