Synthesis, Storage and Release of Choline Analog Esters
It is well accepted that the choline for acetylcholine (ACh) synthesis is delivered to choline acetyltransferase by a process of transport that carries choline from the extracellular space to the cytosol of the cholinergic nerve terminal (see reviews by 11, 12). The acetyl group for ACh synthesis clearly derives from acetyl- -CoA, although the mechanism by which acetyl-CoA is delivered to choline acetyltransferase remains unclear (see 5, 19). The rate of ACh synthesis is known to be regulated according to need so that activity in a cholinergic neurone that releases transmitter turns on ACh synthesis (see 15, 19). The question is: how is this control achieved?
KeywordsSynaptic Vesicle Subcellular Distribution Transmitter Release Choline Uptake Acetyl Ester
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