Advertisement

Synthesis, Storage and Release of Choline Analog Esters

  • B. Collier
  • S. A. Welner
Part of the Advances in Behavioral Biology book series (ABBI, volume 30)

Abstract

It is well accepted that the choline for acetylcholine (ACh) synthesis is delivered to choline acetyltransferase by a process of transport that carries choline from the extracellular space to the cytosol of the cholinergic nerve terminal (see reviews by 11, 12). The acetyl group for ACh synthesis clearly derives from acetyl- -CoA, although the mechanism by which acetyl-CoA is delivered to choline acetyltransferase remains unclear (see 5, 19). The rate of ACh synthesis is known to be regulated according to need so that activity in a cholinergic neurone that releases transmitter turns on ACh synthesis (see 15, 19). The question is: how is this control achieved?

Keywords

Synaptic Vesicle Subcellular Distribution Transmitter Release Choline Uptake Acetyl Ester 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Anderson, D.C., King, S.C. and Parsons, S.M. (1983): Molec. Pharmacol. 24: 48–54.Google Scholar
  2. 2.
    Boksa, P. and Collier, B. (1980): J. Neurochem. 34: 1470–1482.CrossRefGoogle Scholar
  3. 3.
    Boksa, P. and Collier, B. (1980): J. Neurochem. 35: 1099–1104.CrossRefGoogle Scholar
  4. 4.
    Brittain, R.T., Levy,G.P. and Tyers,M.B. (1969): Brit. J. Pharmacol. 36: 173–174.Google Scholar
  5. 5.
    Clark, J.B., Booth, R.F.G., Harvey, S.A.K., Leong, S.F. and Patel,T.B. (1982): In Neurotransmitter Interaction and Compartmentation (ed) H.F. Bradford, Plenum Press, New York,pp. 431–460.Google Scholar
  6. 6.
    Collier, B., Boksa, P. and Lovat, S. (1979):. Progr. Brain. Res. 49: 107–121.Google Scholar
  7. 7.
    Collier, B. and Ilson, D. (1977): J. Physiol. 264: 489–509.Google Scholar
  8. 8.
    Collier, B., Ilson,D. and Lovat, S. (1977): In Cholinergic Mechanisms and Psychopharmacology (ed) D.J. Jenden, Plenum Press, New York, pp. 457–464.Google Scholar
  9. 9.
    Collier, B. and O’Regan, S. (1981): In Cholinergic Mechanisms (eds) G. Pepeu and H. Ladinsky, Plenum Press, New York,pp. 97–107.Google Scholar
  10. 10.
    Jenden,D.J. (1979): In Nutrition and the Brain (eds) A. Barbeau, J.H. Growdon and R.J. Wurtman, Raven Press, New York, pp. 13–24.Google Scholar
  11. 11.
    Jope, R.S. (1979): Brain Res. Rev. 1: 313–344.CrossRefGoogle Scholar
  12. 12.
    Kuhar, M.J. and Murrin, L.C. (1978): J. Neurochem. 30: 15–21.CrossRefGoogle Scholar
  13. 13.
    Kwok, Y.N. and Collier, B. (1982): J. Neurochem. 39: 16–26.CrossRefGoogle Scholar
  14. 14.
    Lugmani, Y.A., Sudlow, G. and Whittaker, V.P. (1980): Neuroscience 5: 153–160.CrossRefGoogle Scholar
  15. 15.
    MacIntosh, F.C. and Collier, B. (1976): In Neuromuscular Junction (ed) E. Zaimis, Springer-Verlag, Berlin, pp. 99–228.Google Scholar
  16. 16.
    Marshall, I.G. (1970); Brit. J. Pharmacol. 38: 503–516.Google Scholar
  17. 17.
    O’Regan, S. and Collier, B. (1981): Neuroscience 6: 511–520.CrossRefGoogle Scholar
  18. 18.
    Potter, L.T., Glover, V.A.S. and Saelens, J.K. (1968): J. Biol. Chem. 243: 3864–3870.Google Scholar
  19. 19.
    Tucek, S. (1978): In Acetylcholine Synthesis in Neurons (eds) Chapman and Hall, London, pp. 1–259.Google Scholar
  20. 20.
    Whittaker,V.P. and Lugmani, Y.A. (1980): Gen. Pharmaco1. 11: 7–14.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • B. Collier
    • 1
  • S. A. Welner
    • 1
  1. 1.Department of PharmacologyMcGill UniversityMontrealCanada

Personalised recommendations