Histochemical and Biochemical Effects of the Injection of AF64A into The Nucleus Basalis of Meynert:Relevance to Animal Models of Senile Dementia of the Alzheimer Type
The fourth largest cause of death in the United States is senile dementia of the Alzheimer type (SDAT; 9). The initial symptom of this disorder is loss of short term memory. This is followed over a period of years by progressive dementia, complete loss of ability to care for oneself and finally, death (16). The most universal neuropathological change seen in victims of SDAT is a loss of acetylcholine in the cerebral cortex (3, 13). This loss appears due to the death of neurons in the nucleus basalis of Meynert (nbM), an area which supplies the cortex with a substantial proportion of its cholinergic innervation (8, 17). Thus animals with selective lesions of the nbM may be useful models of SDAT in humans.
KeywordsAChE Activity Senile Dementia Lesion Hemisphere ChAT Activity Choline Acetyl
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