Biochemical and Behavioral Effects of Ethylcholine Mustard Aziridinium Ion

  • F. Casamenti
  • L. Bracco
  • F. Pedata
  • G. Pepeu
Part of the Advances in Behavioral Biology book series (ABBI, volume 30)


The most important biochemical change detected in the brain of patients affected by senile dementia of Alzheimer type is a decrease in choline acetyltransferase (ChAT) activity in the cerebral cortex and hippocampus (17). The decrease is caused by a loss of cholinergic fibers originating from the magnocellular forebrain nuclei and the septum (2).


Senile Dementia ChAT Activity Cholinergic Fiber Choline Acetyl High Affinity Choline Uptake 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • F. Casamenti
    • 1
  • L. Bracco
    • 2
  • F. Pedata
    • 1
  • G. Pepeu
    • 1
  1. 1.Department of PharmacologyUniversity of FlorenceFlorenceItaly
  2. 2.Neurological ClinicUniversity of Florence CareggiFlorenceItaly

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