Acetylcholine — Prostanoid Interaction in the Pulmonary Circulation
Parasympathetic innervation of pulmonary arteries and/or veins has been identified histologically in many species and is achieved via the tenth cranial nerve (vagus; 5, 6). The pulmon- ary hemodynamic alterations resulting from vagal stimulation or administration of muscarinic agonists, however, remain controversial. Over the last fifty years, sporadic investigations have proposed that acetylcholine (ACh) causes vasoconstriction in the pulmonary circulation of the dog, monkey, rabbit, rat, guinea pig, cat, frog and sheep; however others have observed vasodilation in the pulmonary circulation of dog, cat and pig (for review, see ref. 1). Some of the factors that could be responsible for the apparent discrepancy in these findings include adrenergic discharge or concomitant bronchoconstriction contributing to pulmonary vasoconstriction, and cholinergic — induced bradycardia, systemic hypotension and decreased cardiac output causing secondary pulmonary vasodilation.
KeywordsAirway Pressure Pulmonary Vascular Resistance Airway Smooth Muscle Vagal Stimulation Pulmonary Arterial Pressure
Unable to display preview. Download preview PDF.
- 1.Aviado, D.M. (1965): ed. The Lung Circulation, Pergamon Press, New York.Google Scholar
- 2.Bakhle, Y.S. (1981): Bull, Europ. Physiopath. Resp. 17: 491–508.Google Scholar
- 3.Borda, E., Agostini,M.D.C., Peredo,H., Gimeno, M.F. and Gimeno, A.L. (1983): Arch. Int. Pharmacodyn 263: 245–253.Google Scholar
- 4.Effros, R., Shapiro, L. and Silverman, P. (1980): J. Appl. Physiol. 49: 589–600.Google Scholar
- 8.Johnson, A.R., Callahan, K.S., Tsai, S.C. and Campbell, W.B. (1981): Bull. Europ. Physiopath. Resp. 17: 531–551.Google Scholar
- 9.Junstad, M. and Wennmalm, A. (1974): Br. J. Pharmacol. 52: 375–379.Google Scholar
- 11.Snedecor, G.W. and Cochran, W.G. (1980): Statistical Methods, 7th ed., Iowa State Press, Ames.Google Scholar