Tendency for Repetitive Vagal Activity to Synchronize Cardiac Pacemaker Cells

  • M. N. Levy
  • T. Yang
Part of the Advances in Behavioral Biology book series (ABBI, volume 30)


There are thousands of cells in the sinoatrial (S-A) node of the mammalian heart that possess the property of automaticity; i.e., each is able to generate impulses independently. The cell-to-cell communication among these automatic cells is notoriously poor. Very little information is available about the natural mechanisms that serve to coordinate the activities of the cells in the S-A node. Recent evidence (4, 7, 8, 18, 19) indicates that the “phase-dependency” of the cardiac response to vagal stimulation is one mechanism that provides some coordination of automatic cell firing; “phase-dependency” refers to the tendency for the cardiac response to a vagal action potential to depend on the timing of that action potential within the cardiac cycle.


Cardiac Cycle Vagal Stimulation Vagal Activity Pacemaker Cell Automatic Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • M. N. Levy
    • 1
  • T. Yang
    • 1
  1. 1.The Mt. Sinai Medical CenterCase Western Reserve UniversityClevelandUSA

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