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Selective Facilitatory Effects of Vasoactive Intestinal Polypeptide on Muscarinic Mechanisms in Sympathetic and Parasympathetic Ganglia of the Cat

  • M. Kawatani
  • M. Rutigliano
  • W. C. deGroat
Part of the Advances in Behavioral Biology book series (ABBI, volume 30)

Abstract

Vasoactive intestinal polypeptide (VIP) is widely distributed in the mammalian peripheral nervous system (11, 13, 15, 16, 17, 18) and is frequently localized at sites of cholinergic transmission (17, 18, 26, 27, 28). At some cholinergic synapses VIP has been identified as a cotransmitter released with acetylcholine (ACh) (5, 17, 26, 28, 29). The functions and interactions of these co-transmitters have been studied extensively in the cholinergic innervation of the salivary and sweat glands of the cat (2, 26, 27, 28, 29). At both sites it has been demonstrated that neurally released VIP and ACh can produce independent responses, i.e., vasodilation by VIP and secretion by ACh. In addition, in the salivary gland, VIP and ACh have synergistic effects on secretory cells. This synergistic interaction is unusual since VIP does not directly stimulate glandular secretion but rather enhances the secretory effect of ACh, possibly by increasing the affinity for ACh of the muscarinic receptors on the gland cells (30). Thus, VIP appears to be a neuromodulator as well as neurotransmitter at cholinergic synapses in salivary glands.

Keywords

Salivary Gland Muscarinic Receptor Facilitatory Effect Vasoactive Intestinal Polypeptide Superior Cervical Ganglion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • M. Kawatani
    • 1
  • M. Rutigliano
    • 1
  • W. C. deGroat
    • 1
  1. 1.Department of Pharmacology, Medical SchoolUniversity of PittsburghPittsburghUSA

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