Vasoactive Intestinal Polypeptide-Muscarinic Cholinergic Interactions

  • B. Hedlund
  • J. Abens
  • A. Westlind
  • T. Bartfai
Part of the Advances in Behavioral Biology book series (ABBI, volume 30)


Coexistence of a classical neurotransmitter and a peptide neurotransmitter in the same neuron in the peripheral or central nervous system has been described in a large number of cases (cf. for review (10)). The peptide which has been described to occur together with acetylcholine in the parasympathetic neurons innervating the cat submandibular salivary gland is VIP, the vasoactive intestinal polypeptide (cf. 12). VIP, a 28 aminoacid long peptide with a C-terminal amide, belongs to the secretin family. It was isolated by Said and Mutt (17) from porcine gut and it appears that the aminoacid sequence of the porcine and human VIP is identical.


Salivary Gland Adenylate Cyclase Muscarinic Receptor Vasoactive Intestinal Polypeptide Bipolar Cell 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • B. Hedlund
    • 1
  • J. Abens
    • 1
  • A. Westlind
    • 1
  • T. Bartfai
    • 1
  1. 1.Department of Biochemistry, Arrhenius LaboratoryUniversity of StockholmStockholmSweden

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