Dopamine D1-Receptor Binding in the Living Human Brain
The neurotransmitter dopamine, which plays a role in the pathophysiology of Parkinson’s Disease and possibly also schizophrenia, mediates its actions in the brain by at least two types of receptors (Kebabian and Calne, 1979). By the activation of the dopamine D1 receptor, dopamine stimulates the enzyme adenylate cyclase (Kebabian et al., 1972). Activation of the dopamine D2 receptor is not, or is possibly negatively, coupled to a dopamine sensitive adenylate cyclase (Stoof and Kebabian, 1984). Many behavioural effects of dopamine seem to be mediated by D2 receptors (Peroutka and Snyder, 1980). The analysis of D2 receptors has been facilitated by the availability of selective drugs interacting with this receptor. The exploration of dopamine D1 receptor characteristics and function has been hampered by the previous lack of such pharmacological tools.
KeywordsPositron Emission Tomography Dopamine Receptor Adenylate Cyclase Neocortical Area Caudate Putamen
Unable to display preview. Download preview PDF.
- Farde, L., Ehrin, E., Eriksson, L., Greitz, T., Hall, H. Hedstrom, CG., Litton, J-E. and Sedvall, G., 1985, Substituted benzamides as ligands for visualization of dopamine receptor binding in the human brain by positron emission tomography, Proc. Natl. Acad. Sci., 82:3863.PubMedCrossRefGoogle Scholar
- Halldin, C., Stone-Elander, S., Farde, L., Ehrin, E., Fasth, K.J., Langstrom, B. and Sedvall, G., 1986, Preparation of 11C labelled SCH 23390 for the in vivo analysis of dopamine D1 receptors by positron emission tomography, J. Appl. Radiochem. Isotop, In press.Google Scholar
- Peroutka, S.J. and Snyder, S.H., 1980, Relationship of neuroleptic drug effects at brain dopamine, serotonin, alpha-adrenergic, and histamine receptors to clinical potency, Am. J. Psychiatry 173:12, 1518–1522.Google Scholar
- Sedvall, G., Blomqvist, G., dePaulis, S., Ehrin, E., Eriksson, L., Farde, L., Greitz, T. Hedstrom, C.G., Ingvar, D.H., Litton, J.E., Nilsson, J.L.G., Stone-Elander, S., Widen, L., Wiesel, F.A. and Wik, G., 1983, 11-C-labelled benzamides as ligands for imaging of dopamine receptors in the human brain, 1983 ACNP Annual Meeting, San Juan, December 12–16.Google Scholar