Quantitative Autoradiographic Localization of Central Dopamine D-1 and D-2 Receptors

  • Ted M. Dawson
  • Donald R. Gehlert
  • James K. Wamsley
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 204)


Interest in the role of dopamine (DA) as a neurotransmitter within the central nervous system has been increasing markedly over the last several years (Kaiser and Jain, 1985); in fact, it has become the “most extensively investigated neurotransmitter in the nervous system” (Kaiser and Jain, 1985). One area that has been the subject of intensive research is the study of DA receptors. Controversies exist on the actual number of different types of DA receptors, but based on dopamine stimulated adenylate cyclase activity (Kebabian and Calne, 1979; Stoof and Kebabian, 1984) there are primarily two subtypes of DA receptors. The dopamine type-1 (D-1) receptor which is positively associated with adenylate cyclase, and the dopamine type-2 (D-2) receptor which is not associated with this enzyme or, more appropriately, negatively linked.


Dopamine Receptor Adenylate Cyclase Globus Pallidus Dopamine Receptor Agonist Dopaminergic Agonist 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Ted M. Dawson
    • 1
  • Donald R. Gehlert
    • 1
  • James K. Wamsley
    • 1
  1. 1.Departments of Psychiatry and PharmacologyUniversity of Utah School of MedicineSalt Lake CityUSA

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