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Quantitative Autoradiographic Localization of Central Dopamine D-1 and D-2 Receptors

  • Chapter
Neurobiology of Central D1-Dopamine Receptors

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 204))

Abstract

Interest in the role of dopamine (DA) as a neurotransmitter within the central nervous system has been increasing markedly over the last several years (Kaiser and Jain, 1985); in fact, it has become the “most extensively investigated neurotransmitter in the nervous system” (Kaiser and Jain, 1985). One area that has been the subject of intensive research is the study of DA receptors. Controversies exist on the actual number of different types of DA receptors, but based on dopamine stimulated adenylate cyclase activity (Kebabian and Calne, 1979; Stoof and Kebabian, 1984) there are primarily two subtypes of DA receptors. The dopamine type-1 (D-1) receptor which is positively associated with adenylate cyclase, and the dopamine type-2 (D-2) receptor which is not associated with this enzyme or, more appropriately, negatively linked.

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  1. Donald R. Gehlert

    Present address: National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, 20205, USA

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  1. Departments of Psychiatry and Pharmacology, University of Utah School of Medicine, Salt Lake City, Utah, 84132, USA

    Ted M. Dawson, Donald R. Gehlert & James K. Wamsley

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  1. Ted M. Dawson
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  1. University of North Carolina at Chapel Hill, Chapel Hill, North Caronila, USA

    George R. Breese

  2. University of California, San Diego, La Jolla, Carlifornia, USA

    Ian Creese

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© 1986 Plenum Press, New York

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Dawson, T.M., Gehlert, D.R., Wamsley, J.K. (1986). Quantitative Autoradiographic Localization of Central Dopamine D-1 and D-2 Receptors. In: Breese, G.R., Creese, I. (eds) Neurobiology of Central D1-Dopamine Receptors. Advances in Experimental Medicine and Biology, vol 204. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5191-7_6

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  • DOI: https://doi.org/10.1007/978-1-4684-5191-7_6

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