The Multiplicity of the D1 Dopamine Receptor

  • Richard B. Mailman
  • David W. Schulz
  • Clinton D. Kilts
  • Mark H. Lewis
  • Hans Rollema
  • Steven Wyrick
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 204)


Dopaminergic neurotransmission is known to modulate a variety of behaviors, including ambulation (Ungerstedt and Arbuthnott, 1970; Pijnenburg et al., 1976), stereotyped behaviors (Creese and Iversen, 1973), self-stimulation (Phillips and Fibiger, 1973), conditioned avoidance responding (Seiden and Carlsson, 1963), stimulus control (Ho and Huang, 1975), and feeding and drinking (Ungerstedt, 1971; Fitzsimons and Setler, 1975). It is not surprising, therefore, that drugs which are believed to act primarily as dopamine receptor agonists or antagonists have important clinical utility. Our work has sought to address two questions of some neuropharmacological importance. First, what is the nature of mechanisms by which dopamine initiates many of these psychopharmacological effects, and second, is it possible to design highly specific drugs targeted only at a selected subpopulation of dopamine receptors?


Dopamine Receptor Adenylate Cyclase Antipsychotic Drug Adenylate Cyclase Activity Dopamine Receptor Agonist 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Richard B. Mailman
    • 1
    • 2
    • 3
  • David W. Schulz
    • 1
    • 3
  • Clinton D. Kilts
    • 5
  • Mark H. Lewis
    • 1
  • Hans Rollema
    • 6
  • Steven Wyrick
    • 4
  1. 1.Biological Sciences Research CenterUniversity of North Carolina School of MedicineChapel HillUSA
  2. 2.Departments of Psychiatry and PharmacologyUniversity of North Carolina School of MedicineChapel HillUSA
  3. 3.Neurobiology CurriculumUniversity of North Carolina School of MedicineChapel HillUSA
  4. 4.Department of Medicinal ChemistryUniversity of North Carolina School of MedicineChapel HillUSA
  5. 5.Department of PsychiatryDuke University Medical CenterDurhamUSA
  6. 6.ReiksuniversiteitGroningenNetherlands

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