Interaction of D1 and D2 Dopamine Receptors in the Expression of Dopamine Agonist Induced Behaviors
The study of behaviors induced by centrally acting dopaminergic agents is a classical means of investigating the pharmacology of the dopamine system and the pathophysiology of human neuropsychiatric diseases for which these behaviors serve as animal models. Observation and quantification of stereotypic and nonstereotypic behaviors has been a standard research protocol since the earliest work on the central activity of amphetamine and related agents (Randrup and Munkvad, 1967; Kelly and Iversen, 1975). Quantification of rotational behavior in lesioned rats (Ungerstedt and Arbuthnott, 1970) has more recently become an established means of investigating the activity of dopaminergic agents within the CNS. The compartmentalization of dopamine receptors on the basis of their ability to stimulate (D1 receptors) or not stimulate (D2 receptors) adenylate cyclase (Kebabian and Calne, 1979) and the introduction of agents selective for these receptor subtypes have provided the means with which to extend the classical behavioral observations and to utilize these techniques to more comprehensively characterize the pharmacology of the central dopamine system.
Unable to display preview. Download preview PDF.
- Barone, P., T.A. Davis, A.R. Braun, and T.N. Chase, 1986, Dopaminrgic mechanisms and motor function: Characterization of D1 and D2 receptor interactions, European J. Pharmacol., in press.Google Scholar
- Braun, A.R., P. Barone, and T.N. Chase, D1 D2 receptor interaction in the generation of dopamine agonist related behaviors, submitted.Google Scholar
- Dawson, T.M. D.R. Gehlert, R.T. McCabe, A. Barnett and J.K. Wamsley, 1986, D1 dopamine receptors in the rat brain: A quantitative autoradiographic analysis, J. Neuroscience, in press.Google Scholar
- Lyon, M., and T. Robbins, 1975, The action of central nervous system stimulant drugs: A general theory concerning amphetamine effects, Current Developments in Psychopharmacology, 2: 79.Google Scholar