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Benzazepines: Structure-Activity Relationships Between D1 Receptor Blockade and Selected Pharmacological Effects

  • Louis C. Iorio
  • Allen Barnett
  • William Billard
  • Elijah H. Gold
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 204)

Abstract

SCH 23390 is (R)-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1-H-3-benzazepine. Its synthesis was based on the benzazepine series synthesized more than 15 years ago by Dr. Lewis Walter and Mr. Wei Chang at Schering Research Laboratories, and highlighted by the work done with the 7,8-dimethoxy analog of SCH 23390, SCH 12679. This earlier-described drug (Barnett et al., 1974) manifested potent inhibition of aggression invoked in animals by such diverse methods as social isolation, septal and olfactory bulb lesions and electrical stimulation, and aggression occurring spontaneously in monkeys (attack phenomena) and rats (muricide). With respect to antipsychotic potential, SCH 12679 did differ from the standards in that it did not block conditioned avoidance responding (CAR) in rats, an effect which we consider an important index of antipsychotic potential.

Keywords

Adenylate Cyclase Chronic Schizophrenic Wire Mesh Screen Spiperone Binding Nitrogen Lone Electron Pair 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Louis C. Iorio
    • 1
  • Allen Barnett
    • 1
  • William Billard
    • 1
  • Elijah H. Gold
    • 1
  1. 1.Schering ResearchBloomfieldUSA

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