Verapamil Inhibits the Respiration Rate of Cancer Cells
Calcium antagonists have successfully been used in the treatment of hypertension, cardiac arrhythmias and coronary heart disease. Recent evidence has suggested that such agents may also play a role in the treatment of malignant tumors. Verapamil, a calcium entry blocker, has been reported to enhance the cytotoxicity of several anticancer drugs under in vitro- and in vivo-conditions [1–10]. The effects observed could be explained by an enhanced drug accumulation due to a Verapamil-induced inhibition of the drug efflux from the cancer cells.
KeywordsCalcium Antagonist Antineoplastic Agent Ehrlich Ascites Carcinoma Calcium Entry Blocker Human Bladder Cancer Cell
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