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Correlation between Mitochondrial Respiratory Dysfunction and Na+-Reabsorption in the Reoxygenated Rat Kidney

  • G. Gronow
  • Ch. Skrezek
  • H. Kossmann
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 200)

Abstract

At normal rates of renal blood flow, a marked reduction of glomerular filtration rate (GFR) has been observed in the postischemic kidney (Arendshorst et al., 1975; Williams et al., 1981). This decrease in GFR, which is a major determinant of acute renal failure (ARF), was mediated by preceding ischemic alterations at the cellular level: an impairment of volume regulation initiated swelling of tubular cells and cell organelles, thus increasing intratubular pressure and reducing effective filtration pressure (Venkatachalam et al., 1978; Johnston et al., 1984). Apparently, despite high rates of oxygen delivery to renal tissue during reoxygenation, a recovery of organ function was prevented by irreversible cellular alterations in the postischemic kidney.

Keywords

Glomerular Filtration Rate Severe Hypoxia Perfusion Flow Rate Plasma Substrate REOXYGENATION Period 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • G. Gronow
    • 1
  • Ch. Skrezek
    • 1
  • H. Kossmann
    • 1
  1. 1.Department of PhysiologyUniversity of KielFederal Republic of Germany

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