Correlation between Mitochondrial Respiratory Dysfunction and Na+-Reabsorption in the Reoxygenated Rat Kidney

  • G. Gronow
  • Ch. Skrezek
  • H. Kossmann
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 200)


At normal rates of renal blood flow, a marked reduction of glomerular filtration rate (GFR) has been observed in the postischemic kidney (Arendshorst et al., 1975; Williams et al., 1981). This decrease in GFR, which is a major determinant of acute renal failure (ARF), was mediated by preceding ischemic alterations at the cellular level: an impairment of volume regulation initiated swelling of tubular cells and cell organelles, thus increasing intratubular pressure and reducing effective filtration pressure (Venkatachalam et al., 1978; Johnston et al., 1984). Apparently, despite high rates of oxygen delivery to renal tissue during reoxygenation, a recovery of organ function was prevented by irreversible cellular alterations in the postischemic kidney.


Glomerular Filtration Rate Severe Hypoxia Perfusion Flow Rate Plasma Substrate REOXYGENATION Period 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • G. Gronow
    • 1
  • Ch. Skrezek
    • 1
  • H. Kossmann
    • 1
  1. 1.Department of PhysiologyUniversity of KielFederal Republic of Germany

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