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Lowered Oxygen Supply and Calcium (Ca) Accumulation in Rabbit Proximal Tubules

  • Takehito Takano
  • Stephen P. Soltoff
  • Susan Murdaugh
  • Lazaro J. Mandel
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 200)

Abstract

Most ischemia studies in intact animals have been performed by clamping the arteries, and there are some discrepancies as to the Ca accumulation caused by ischemia. We measured Ca contents and redox states of cytochrome aa3 (cyt aa3) in the suspension of rabbit proximal tubules to investigate a relationship between the degree of lowered oxygen supply and the degree of Ca accumulation in the tubule cells at the initial phase of hypoxic insult. “Initial phase of hypoxia” is used as the hypoxia within 30 min in the present study.

Keywords

Severe Hypoxia Hypoxic Insult Percent Oxidation Electrochemical Potential Difference Lower Oxygen Supply 
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References

  1. 1.
    R.S. Balaban, S.P. Soltoff, J.M. Storey and L.J. Mandel, Improved renal cortical tubule suspension: spectrophotometric study of O2 delivery, Am. J. Physiol. 238: F50 (1980)PubMedGoogle Scholar
  2. 2.
    S.P. Soltoff and L.J. Mandel, Active ion transport in the renal proximal tubule. I. Transport and metabolic studies, J. Gen. Physiol. 84: 601 (1984)PubMedCrossRefGoogle Scholar
  3. 3.
    T. Takano, S.P. Soltoff, S. Murdaugh and L.J. Mandel, Intracellular respiratory dysfunction and cell injuly in short-term anoxia of rabbit renal proximal tubules, J. Clin. Invest. (in press)Google Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Takehito Takano
    • 1
  • Stephen P. Soltoff
    • 1
  • Susan Murdaugh
    • 1
  • Lazaro J. Mandel
    • 1
  1. 1.Dept. of PhysiologyDuke University Medical CenterDurhamUSA

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