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Influence of Liver Cirrhosis and Spontaneous Portasystemic Shunting on Muscle PO2 at Rest and Work

  • R. Heinrich
  • M. Günderoth-Palmowski
  • W. Grauer
  • P. Boekstegers
  • W. Späth
  • W. Fleckenstein
  • H. Schomerus
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 200)

Abstract

The well known hyperdynamic syndrome of patients with liver cirrhosis is not necessarily dependent on liver cell function, because a portacaval anastomosis in mammalians with intact liver function leads to comparable changes of the systemic circulation: increase of cardiac output, and systolic ejection rate. Preliminary results of muscle pO2 of rats with liver cirrhosis indicate that with development of portosystemic collaterals due to portal hypertension and increasing hyperperfusion at rest mean tissue pO2 of the M. rectus abdominis increases (1, 2, 3). The aim of our study was to evaluate the effect of slowly increasing hypercirculation due to pharmacologically induced liver cirrhosis/fibrosis on tissue pO2 of the M. biceps femoris at rest and work.

Keywords

Liver Cirrhosis Portal Hypertension Biceps Femoris Intact Control Ejection Rate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • R. Heinrich
    • 1
    • 2
  • M. Günderoth-Palmowski
    • 1
    • 2
  • W. Grauer
    • 1
    • 2
  • P. Boekstegers
    • 1
    • 2
  • W. Späth
    • 1
    • 2
  • W. Fleckenstein
    • 1
    • 2
  • H. Schomerus
    • 1
    • 2
  1. 1.Med. Univ. Klinik (Abtlg. I)TübingenGermany
  2. 2.Institut für PhysiologieMed. Hochschule LübeckGermany

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