Control of O2 Supply to the Pancreas during a Vasopressin-Induced Vasoconstriction

  • H. J. M. Beijer
  • G. A. Charbon
  • M. Woerlee
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 200)


In the anesthetized dog, the metabolic level of the pancreas was elevated by a secretin infusion (1.2 U/kg/hr iv), displaying a metabolic control of tissue oxygenation and blood flow. Question was raised how this system would response to a decrease in O2 supply, as induced by increasing doses of vasopressin (2–131 mU/kg, iv). These vasopressin administrations progressively diminished blood flow (down to 20%), as well as secretory rate (down to 7%) and O2 consumption (down to 33%). The O2 extraction was increased up to 227%. Capillary density, mitochondrial O2 consumption, capillary PO2 and cellular PO2 were calculated by simulating these data with the model of the metabolic control of tissue oxygenation. The changes mentioned above could be simulated adequately. These simulations revealed that a. in the pancreas vasopressin primarily increases arteriolar resistance; the inhibition of metabolism is secondary to the vasopressin-induced vasoconstriction. b. The pancreas responds with a small compensatory capillary recruitment (up to 29%), which in itself would increase tissue oxygenation. c. The main consequence of the lowering of blood flow is a dramatic decrease of mean capillary PO2 (down to 38%), as well as a lowering in mean cellular PO2 (down to 41%). This lowering of O2 supply to the tissue will slow down the metabolic rate, as evidenced by the decrease of the volume of the excretion.


Secretory Rate Capillary Density Exocrine Secretion Lower Blood Flow Arteriolar Resistance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Conn H.O., Ramsby G.R., Storer E.H., Mutchnich M.G., Joshi P.H., Phillips M.M., Cohen G.A., Fields G.N., Petroski D. (1975). Intra-arterial vasopressin in the treatment of upper gastrointestinal hemorrhage: a prospective, controlled clinical trial. Gastroenterology 68: 211–221.Google Scholar
  2. 2.
    Johnson W.C., Widrich W.C., Ansell J.E., Robbins A.H., Nabseth D.C. (1977). Control of bleeding varices by vasopressin a prospective randomized study. Ann Surg 186: 369–376.Google Scholar
  3. 3.
    Swan K.G., Hobson R.W., Kerr J.C. (1977). Vasopressin and control of gastrointestinal hemorrhage: experimental observations and clinical recommendations. Am Surg 43: 545.PubMedGoogle Scholar
  4. 4.
    Athanasoulis C.A., Waltman A.C., Simmons J.T., Sheehan B., Coggins C.H. (1978). Effects of intravenous vasopressin on canine mesenteric arterial blood flow, bowel oxygen consumption, and cardiac output. Am J Roentgenol 130: 1035–1039.Google Scholar
  5. 5.
    Groszmann R.J., Blei A.T., Storer E.H., Conn H.O. (1980). Intestinal 02 consumption during mechanical and pharmacological reduction in portal pressure. Am J Physiol 243: G502–G508.Google Scholar
  6. 6.
    Lote K, Foiling M., Lekven J., Rosengren B. (1981). Mesenteric arterial vasopressin in cats: local and systemic effects. Am J Roentgenol 136: 969–975.Google Scholar
  7. 7.
    Schapiro H. (1975). Inhibitory action of antidiuretic hormone on canine pancreatic exocrine flow. Am J Dig Dis 20: 853–857.Google Scholar
  8. 8.
    Schuurkes J.A.J., Brouwers H.A.A., Beijer H.J.M., Charbon G.A, Schapiro H. (1976). Lysine-vasopressin: hemodynamic effects in the anesthetized dog. Am J Dig Dis 21: 1012–1019.Google Scholar
  9. 9.
    Wolfson Ph, Cort J.H., Dreiling D.A. (1979). Mechanism of vasopressin inhibition of pancreatic secretion. Am J Gastroenterol 71: 490–495.Google Scholar
  10. 10.
    Shepherd A.P., Granger H.J. (1973). Autoregulatory escape in the gut: a system analysis. Gastroenterology 65: 77-91.Google Scholar
  11. 11.
    Granger H.J., Shepherd A.P. (1979). Dynamics and control of the microcirculation. Adv Biomed Eugin 7: 1–63.Google Scholar
  12. 12.
    Granger H.J., Nyhof R.A. (1982). Dynamics of intestinal oxygenation: interactions between oxygen supply and uptake. Editorial review Am J Physiol 243: G91–G96.Google Scholar
  13. 13.
    Shepherd A.P. (1982). Role of capillary recruitment in the regulation of intestinal oxygenation. Am J Physiol 242: G435–G441.Google Scholar
  14. 14.
    Beijer H.J.M., Maas A.H.J., Charbon G.A. (1984). Pancreatic 02 consumption and HCO3 output during secretin-induced exocrine secretion from the pancreas in the anesthetized dog. Pflügers Arch 400: 318–323.PubMedCrossRefGoogle Scholar
  15. 15.
    Beijer H.J.M., Maas A.H.J., Charbon G.A. (1984). A vasopressin-induced decrease in pancreatic blood flow and in pancreatic exocrine secretion in the anesthetized dog. Pflügers Arch 400: 324–328.Google Scholar
  16. 16.
    Beijer H.J.M., Holtgrefe A.G.J., Woerlee M. (1985). Control of 02 supply to the stimulated exocrine pancreas. Int. Soc. on Oxygen Transport to tissue, Nijmegen 1984. Adv. Exp. Med. Biol., Plenum Press, in press.Google Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • H. J. M. Beijer
    • 1
  • G. A. Charbon
    • 1
  • M. Woerlee
    • 2
  1. 1.Exp. Lab. for Peripheral CirculationUniversity HospitalUtrechtThe Netherlands
  2. 2.Department of Theoretical BiologyUniversity HospitalUtrechtThe Netherlands

Personalised recommendations