Control of O2 Supply to the Pancreas during a Cholecystokinin-Induced Increase in Metabolism
In the anesthetized dog, the pancreatic excretion of enzymes and the pancreatic blood flow were stimulated by a cholecystokinin (CCK) shot of 1 U/kg iv. The question raised was: is this augmented blood flow a metabolically controlled hyperemia or is it independent of the metabolic performance. After the administration of CCK, blood flow as well as O2 consumption were increased, while O2 extraction initially remained unchanged but later it increased. Capillary density, mitochondrial O2 consumption, capillary PO2 and cellular PO2 were calculated, using the model of the metabolic control of tissue oxygenation. The changes mentioned above could be simulated rather exactly. These simulations revealed that during the CCK stimulation the pancreas is able to control its O2 supply through a fast decrease of the arteriolar resistance and a slow capillary recruitment. Thus, by a metabolic control the oxygen is sufficiently supplied to the pancreatic tissue.
KeywordsMetabolic Control Capillary Density Exocrine Secretion Arteriolar Resistance Capillary Recruitment
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- 1.Brown J.C., Harper A.A. (1967). Potentiation of secretin stimulation of the pancreas. J Physiol (London) 190: 519–530.Google Scholar
- 2.Hermon-Taylor J, Beaugie J.M. (1972). The action of pure natural cholecystokinin-pancreozymen on the isolated perfused canine pancreas and liver. In: Nobel Symp. XVI. Frontiers in Gastrointestinal Hormone Research, Ed. S. Andersson, Upsala Almqvist and Wicksell.Google Scholar
- 3.Shepherd A.P., Granger H.J. (1973). Autoregulatory escape in the gut: a system analysis. Gastroenterology 65: 77–91.Google Scholar
- 5.Granger H.J., Nyhof R.A. (1982). Dynamics of intestinal oxygenation: interactions between oxygen supply and uptake. Editorial review Am J Physiol 243: G91–G96.Google Scholar
- 6.Beijer H.J.M., Maas A.H.J., Charbon G.A. (1984). Pancreatic 02 con- sumption and CO2 output during secretin-induced, exocrine secretion from the pancreas in the anesthetized dog. Pflügers Arch 400: 318–323.Google Scholar
- 7.Beijer H.J.M., Maas A.H.J., Charbon G.A. (1984). A vasopressin-induced decrease in pancreatic blood flow and in pancreatic exocrine secretion in the anesthetized dog. Pflügers Arch 400: 324–328.Google Scholar
- 8.Beijer H.J.M., Holtgrefe A.J.G., Woerlee M. (1985). Control of 02 supply to the stimulated exocrine pancreas. Int Symp Oxygen Transport to Tissue, Nijmegen 1984, Adv Exp Medicine and Biology, Plenum Press, New York, in press.Google Scholar