Sensitivity of Rabbit Aorta to Altered Oxygen Tension

  • Roland N. Pittman
  • Barbara A. Graham
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 200)


It is generally thought that feedback mechanisms exist in the systemic circulation to match the supply and demand of oxygen in the various tissues. In particular, vascular smooth muscle cells of the microvessels which control tissue blood flow respond appropriately to an imbalance in oxygen supply and demand. Whether the oxygen-linked stimulus is direct, with oxygen acting on some component of the blood vessel wall, or indirect, acting via altered parenchymal cell metabolism, remains an unsettled question.


Contractile Response Adenosine Deaminase Normoxic Condition Isometric Force Blood Vessel Wall 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Roland N. Pittman
    • 1
  • Barbara A. Graham
    • 1
  1. 1.Department of Physiology and BiophysicsMedical College of VirginiaRichmondCanada

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