Capillary Density of the Cardiomyopathic Syrian Hamster

  • H. R. Figulla
  • F. Vetterlein
  • M. Glaubitz
  • H. Kreuzer
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 200)


The human congestive cardiomyopathy is a heart muscle disease of unknown origin, with a yearly mortality rate of about 10%. At the moment cardiac transplantation offers the best therapeutic approach. Although morphological lesions of the large and small arteries could never be detected, there is some evidence that the cause of the disease might be due to microcirculatory disturbance.1 Thus, in the following study the inbred strain 14.6 of Syrian hamsters was used as an experimental model. In such an animal model, the question was studied, whether microcirculatory changes might be involved in the genesis of myopathic development. The hamsters develop cardiomyopathy and muscular dystrophy in a predictable fashion. Beginning at about 30 days of age the hamsters develop progressive myocytolytic necrosis in the heart and skeletal muscle and die usually within 1 year.


Capillary Density Syrian Hamster Myocardial Necrosis Microcirculatory Disturbance Microcirculatory Change 
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  1. 1.
    S. M. Factor, E. H. Sonnenblick: Hypothesis: Is congestive cardiomyopathy caused by a hyperreactive myocardial microcirculation (microvascular) spasm? Amer. J. Cardiol. 50: 1149 (1982)PubMedCrossRefGoogle Scholar
  2. 2.
    S. M. Factor, T. Minase, S. Cho, R. Dominitz, E. H. Sonnenblick: Microvascular spasm in the cardiomyopathic syrian hamster: a preventable cause of focal myocardial necrosis. Circulation 66: 342 (1982)PubMedCrossRefGoogle Scholar
  3. 3.
    K. Lossnitzer, J. Janke, B. Hein, M. Stauch, H. Fleckenstein: Disturbed myocardial calcium metabolism: a possible pathogenetic factor in the hereditary cardiomyopathy of the Syrian hamster. In Recent Advances in Studies on Cardiac Structure and Metabolism, A. Fleckenstein, G. Rona (Eds), Baltimore, University Press 207 (1975)Google Scholar
  4. 4.
    G. Jasmin, E. Bajusz: Prevention of myocardial degeneration in hamsters with hereditary cardiomyopathy. In Recent Advances in Studies on Cardiac Structure and Metabolism, A. Fleckenstein, G. Rona (Eds), Baltimore, University Press 219 (1975)Google Scholar
  5. 5.
    K. Wrogemann, E. G. Nylen: Mitochondrial calcium overloading in cardiomyopathic hamsters. J. Moll. Cell. Cardiol. 10: 185 (1978)CrossRefGoogle Scholar
  6. 6.
    F. Vetterlein, H. DalRi, G. Schmidt: Capillary density in rat myocardium during timed plasma staining. Am. J. Physiol. 242: H 133 (1982)Google Scholar
  7. 7.
    I. L. Geft, M. C. Fishbein, K. Ninomiya, J. Hashida, E. Chaux, J. Yano, J. Y-Rit, T. Genov, W. Shell, W. Ganz: Intermittent brief periods of ischemia have a cumulative effect and may cause myocardial necrosis. Circulation 66: 1150 (1982)PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • H. R. Figulla
    • 1
  • F. Vetterlein
    • 2
  • M. Glaubitz
    • 1
  • H. Kreuzer
    • 1
  1. 1.Department of Internal Medicine, Division of CardiologyUniversity of GoettingenGoettingenWest Germany
  2. 2.Department of Pharmacology and ToxicologyUniversity of GoettingenGoettingenWest Germany

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