Capillary Density of the Cardiomyopathic Syrian Hamster

  • H. R. Figulla
  • F. Vetterlein
  • M. Glaubitz
  • H. Kreuzer
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 200)

Abstract

The human congestive cardiomyopathy is a heart muscle disease of unknown origin, with a yearly mortality rate of about 10%. At the moment cardiac transplantation offers the best therapeutic approach. Although morphological lesions of the large and small arteries could never be detected, there is some evidence that the cause of the disease might be due to microcirculatory disturbance.1 Thus, in the following study the inbred strain 14.6 of Syrian hamsters was used as an experimental model. In such an animal model, the question was studied, whether microcirculatory changes might be involved in the genesis of myopathic development. The hamsters develop cardiomyopathy and muscular dystrophy in a predictable fashion. Beginning at about 30 days of age the hamsters develop progressive myocytolytic necrosis in the heart and skeletal muscle and die usually within 1 year.

Keywords

Catheter Ischemia Shrinkage Cardiomyopathy Cardiol 

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • H. R. Figulla
    • 1
  • F. Vetterlein
    • 2
  • M. Glaubitz
    • 1
  • H. Kreuzer
    • 1
  1. 1.Department of Internal Medicine, Division of CardiologyUniversity of GoettingenGoettingenWest Germany
  2. 2.Department of Pharmacology and ToxicologyUniversity of GoettingenGoettingenWest Germany

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