Capillary Density of the Cardiomyopathic Syrian Hamster
The human congestive cardiomyopathy is a heart muscle disease of unknown origin, with a yearly mortality rate of about 10%. At the moment cardiac transplantation offers the best therapeutic approach. Although morphological lesions of the large and small arteries could never be detected, there is some evidence that the cause of the disease might be due to microcirculatory disturbance.1 Thus, in the following study the inbred strain 14.6 of Syrian hamsters was used as an experimental model. In such an animal model, the question was studied, whether microcirculatory changes might be involved in the genesis of myopathic development. The hamsters develop cardiomyopathy and muscular dystrophy in a predictable fashion. Beginning at about 30 days of age the hamsters develop progressive myocytolytic necrosis in the heart and skeletal muscle and die usually within 1 year.
KeywordsCapillary Density Syrian Hamster Myocardial Necrosis Microcirculatory Disturbance Microcirculatory Change
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- 3.K. Lossnitzer, J. Janke, B. Hein, M. Stauch, H. Fleckenstein: Disturbed myocardial calcium metabolism: a possible pathogenetic factor in the hereditary cardiomyopathy of the Syrian hamster. In Recent Advances in Studies on Cardiac Structure and Metabolism, A. Fleckenstein, G. Rona (Eds), Baltimore, University Press 207 (1975)Google Scholar
- 4.G. Jasmin, E. Bajusz: Prevention of myocardial degeneration in hamsters with hereditary cardiomyopathy. In Recent Advances in Studies on Cardiac Structure and Metabolism, A. Fleckenstein, G. Rona (Eds), Baltimore, University Press 219 (1975)Google Scholar
- 6.F. Vetterlein, H. DalRi, G. Schmidt: Capillary density in rat myocardium during timed plasma staining. Am. J. Physiol. 242: H 133 (1982)Google Scholar