Capillary Density of the Cardiomyopathic Syrian Hamster
The human congestive cardiomyopathy is a heart muscle disease of unknown origin, with a yearly mortality rate of about 10%. At the moment cardiac transplantation offers the best therapeutic approach. Although morphological lesions of the large and small arteries could never be detected, there is some evidence that the cause of the disease might be due to microcirculatory disturbance.1 Thus, in the following study the inbred strain 14.6 of Syrian hamsters was used as an experimental model. In such an animal model, the question was studied, whether microcirculatory changes might be involved in the genesis of myopathic development. The hamsters develop cardiomyopathy and muscular dystrophy in a predictable fashion. Beginning at about 30 days of age the hamsters develop progressive myocytolytic necrosis in the heart and skeletal muscle and die usually within 1 year.
KeywordsCatheter Ischemia Shrinkage Cardiomyopathy Cardiol
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