Effects of Low Hemoglobin Affinity on Coronary Blood Flow in the Isolated Rat Heart
The physiological consequences of lowering blood affinity are still contradictory. With modest P50 increases, it is often difficult to evidence these effects. In another hand a difficulty to analyse the observed result is induced by the side effects due to the manipulations of the blood in order to increase the P50. Rightwards shifts of the O2 dissociation curve (ODC), obtained in lysed and resealed erythrocytes following encapsulation of inositol hexaphosphate (IHP), were recently described by Teisseire et al.11. This procedure led to very large increase in P50 and the goal of this study was to assess the effects of large decrease of hemoglobin affinity on coronary blood flow in blood perfused isolated rat heart.
KeywordsCoronary Sinus Coronary Blood Flow Citrate Dextrose Oxyhemoglobin Dissociation Curve Inositol Hexaphosphate
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