A Role of Prostaglandin I2 in Hypoxia-Induced Increase in Coronary Flow in the Perfused Rat Heart
When cardiac tissue is exposed to hypoxic condition, coronary blood flow increases by means of coronary vasodilatation to compensate for the deficiency of oxygen supply. A variety of neural and humoral factors are involved in the phenomenon (Feigl EO, 1983). Because of its formation in the myocardial tissue and its biochemical and physiological properties, adenosine has been proposed to be the metabolic regulatory factor functioning in the hypoxic tissue. A number of studies conducted by so-called ‘adenosine hypothesis’ have been reported and reviewed by several authors (Berne, 1980).
KeywordsCoronary Flow Left Ventricular Pressure Effluent Perfusate Intracellular Oxygen Concentration Coronary Artery Strip
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