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Oxygen Transport in the Fetal Brain during Painful Stress

  • A. N. Zirakadze
  • P. Y. Kintraya
  • B. I. Kurchishvili
  • T. N. Suladze
  • M. N. Bakradze
  • N. Sh Mchedlishvilli
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 200)

Abstract

Animal experiments revealed that femur fracture in the mature fetus resulted in an increase in the rate of respiration and phosphorylation in isolated mitochondira of brain neurons during the first 8 ± 0.7 min; 15 ± 3.4 min after bone fracture, O2 consumption is reduced both in hemispheres and in pontine regions (without medulla oblongata) but it is more significant in the latter. The studies showed that oxidative phosphorylation in fetal brain mitochondria and ultrastructural changes in neuron mitochondria from various brain regions in bone fracture are identical with those which occur in umbilical vessel ligation. It is concluded that the mature canine and cat fetus has an integrated nociceptive systemic reaction.

Keywords

Femur Fracture Medulla Oblongata Brain Mitochondrion Brain Neuron Umbilical Vessel 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • A. N. Zirakadze
    • 1
  • P. Y. Kintraya
    • 1
  • B. I. Kurchishvili
    • 1
  • T. N. Suladze
    • 1
  • M. N. Bakradze
    • 1
  • N. Sh Mchedlishvilli
    • 1
  1. 1.Academician Chachava K. V. Perinatal MedicineObstetrics and Gynecology Research Institute of the GSSR PHMTbilisiUSSR

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