Abstract
Animal experiments revealed that femur fracture in the mature fetus resulted in an increase in the rate of respiration and phosphorylation in isolated mitochondira of brain neurons during the first 8 ± 0.7 min; 15 ± 3.4 min after bone fracture, O2 consumption is reduced both in hemispheres and in pontine regions (without medulla oblongata) but it is more significant in the latter. The studies showed that oxidative phosphorylation in fetal brain mitochondria and ultrastructural changes in neuron mitochondria from various brain regions in bone fracture are identical with those which occur in umbilical vessel ligation. It is concluded that the mature canine and cat fetus has an integrated nociceptive systemic reaction.
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© 1986 Plenum Press, New York
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Zirakadze, A.N., Kintraya, P.Y., Kurchishvili, B.I., Suladze, T.N., Bakradze, M.N., Mchedlishvilli, N.S. (1986). Oxygen Transport in the Fetal Brain during Painful Stress. In: Longmuir, I.S. (eds) Oxygen Transport to Tissue VIII. Advances in Experimental Medicine and Biology, vol 200. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5188-7_38
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DOI: https://doi.org/10.1007/978-1-4684-5188-7_38
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