The Influence of Moderate Hypothermia on Cerebral Cortex Tissue Oxygen Tension

  • Hermann Metzger
  • Helmut Brüggemann
  • Anke Plewnia
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 200)


The validity of mechanisms balancing oxygen transport and consumption in hypothermia are difficult to analyse because almost any parameter of the transport system is temperature dependent. Two types of experiments have been performed in the rat cerebral cortex to elucidate this problem:
  1. I)

    PO2 microelectrode study: 32–37°C bodytemperature, spontaneous respiration. Measurements within the upper tissue layer of 200–500 um thickness (N=15).

  2. II)

    PO2 surface electrode study: 26–37°C body temperature, artificial respiration. Investigation of the arachnoidal and pial area (N=46).



Cerebral Blood Flow Mean Arterial Pressure Spontaneous Respiration Local Cerebral Blood Flow Heat Exchanger System 
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  1. Albers, C.,1957, Blutgase in Hypothermie, Verh. dtsch. Ges. Kreislaufforsch., 23: 53–61.Google Scholar
  2. Albers, C., Brendel, W., Hardewig, A., and Usinger,W.,l958, Blutgase in HypothermieGoogle Scholar
  3. Pflügers Arch. ges. Physiol., 266:373–393.Google Scholar
  4. Astrup, P., Engel, K., Severinghaus, J.W., and Muson, E., 1965, The influence of Temperature and pH on the DissociationGoogle Scholar
  5. Curve of Oxyhemoglobin of Human Blood in Vitro, Scand. J. clin. Lab. Invest., 17: 515–519.Google Scholar
  6. Bradley, A.F., Stupfel, M., and Severinghaus, J.W.,1956, Effect of Temperature on PCO2 and P02 of Blood in Vitro, J. Appl. Physiol.,9:2o1–2o5.Google Scholar
  7. Hägerdal, M., Keykhah, M., Perez, E., and Harp, J.R.,1979, Additive Effects of Hypothermia and Phenobarbitol upon Cerebral Oxygen Consumption in the Rat,Acta Anaesthesiol. Scand., 23: 89–92.PubMedCrossRefGoogle Scholar
  8. Hägerdal, M., Harp, J., Nilsson, L., and Siesjö, B.K.,1975, The Effect of Induced Hypothermia upon Oxygen Consumption in the Rat Brain,J. Neurochem., 24: 311–316.Google Scholar
  9. Herrschaft, H., Schmidt, H., Gleim, F., and Albus, G., The Response of Human Cerebral Blood Flow to Anaesthesia with Thiopentone, Methohexitone, Propanidid, Ketamine,and Etomidate, In, In:“Brain Hypoxia-Pain”, H. Penzholz, M.Brock, J.Hammer, M.Klinger, and O. Spoerri., Springer, BerlinHeidelberg-New York (Adv. Neurosurg. Vol. 3): 12o–133 (1975).Google Scholar
  10. Heuser,D.,1982, Die Kopplung von cerebralem Metabolismus und Perfusion bei Anwendung moderner Anästhesieverfahren, Funktionsanal. biol. Syst. 8: lol7–1o22.Google Scholar
  11. Lafferty, J.J., Keykhah, M.M., Shapiro, H.M., Van Horn, K., and Behar, M.G.,1978, Cerebral Hypometabolism Obtained with Deep Pentobarbital Anaesthesia and Hypothermia (30°C), Anaesthesiol., 29: 159–164.CrossRefGoogle Scholar
  12. Metzger, H., Erdmann, W., and Thews, G.,1971, Effect of short Periods of Hypoxia, Hyperoxia and Hypercapnia on Brain 02 supply, J. Appl. Physiol.,31: 751–759.PubMedGoogle Scholar
  13. Metzger, H.,, S., Steinacker, A., and Strüber, J., 1980, Staining PO Measurement Sites in the Rat Brain Cortex and Quantitative Morphometry of the Surrounding Capillaries,Pfl. Arch., 388: 21–27.Google Scholar
  14. Metzger, H., and Heuber-Metzger, S.,(in press), Effects of Hypovolemic Hypotension on the Cerebral Oxygen Supply of Rats with Slightly Raised or Lowered Body Temperature,Microvasc. Res.Google Scholar
  15. Michenfelder, J.D., and Theye, R.A.,1968, Hypothermia: Effect on Canine Brain and Wholebody Metabolism,Anaesthesiol., 29: 11o7–1112.CrossRefGoogle Scholar
  16. Iilsson, L., Kogure, K., and Busto, R., 1975, Effects of Hypothermia and Hyperthermia on Brain Energy Metabolism,Acta Anaesthesiol. Scand.,19: 199–2o5.Google Scholar
  17. Nordström, C.H., and Rehncrona, S., 1978, Reduction of Cerebral Blood Flow and Oxygen Consumption with a Combination of Barbiturate Anaesthesia and Induced Hypothermia in the Rat, Acta Anaesthesiol. Scand., 22: 7–12.Google Scholar
  18. Severinghaus, J.W., 1965, Blood Gas Concentrations, Handb. Physiol., Resp. 2: 1475–1487.Google Scholar
  19. Takeshita, H., Okuda, Y., and Sari, A., 1972, The Effects of Ketamine on Cerebral Circulation and Metabolism in Man, Anesthesiol., 36: 69–75.Google Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Hermann Metzger
    • 1
  • Helmut Brüggemann
    • 1
  • Anke Plewnia
    • 1
  1. 1.Dept. PhysiologyMedizinische Hochschule HannoverHannover 61Federal Republic of Germany

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