Calcium Entry Blockers Protect Brain Energy Metabolism Against Ischemic Damage

  • J. Krieglstein
  • J. Weber
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 200)


Under physiological conditions the intracellular calcium ion activity is regulated at a level several orders of magnitude lower than that of the extracellular space. However, under the conditions of energy failure the cytosolic Ca2+ concentration increases markedly. The reasons for this are the opening of the voltage-dependent calcium channels within the plasma membrane, the release of Ca2+ from the ATP-dependent sites of sequestration in the endoplasmatic reticulum and the impaired ability of mitochondria to accumulate calcium. The resulting increase in free cytosolic calcium activity disrupts a variety of cellular functions and, in particular, may be responsible in part for the breakdown of membrane phospholipids.


Reperfusion Period Calcium Entry Blocker Adenylate Energy Charge Brain Energy Metabolism Adenylate Pool 


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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • J. Krieglstein
    • 1
  • J. Weber
    • 1
  1. 1.Institut für Pharmakologie und Toxikologie, Fachbereich Pharmazie und LebensmittelchemiePhilipps-UniversitätMarburgGermany

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