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Microcirculation and Mitochondrial Function in Focal Brain Ischemia

  • Eörs Dóra
  • Joel H. Greenberg
  • Kortaro Tanaka
  • Nicholas H. Gonatas
  • Martin Reivich
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 200)

Abstract

It is well-established that ischemia leads to very complex and heterogenous changes in microcirculation and metabolism of the brain /Siesjö, 1981; Raichle, 1983; Welsh, 1984/. Although the severity of brain damage depends mainly on the degree and duration of the decrease of cerebral blood flow /CBF/, and hence the depletion of macroerg phosphates, mitochondria seem quite resistant to ischemia /Ikrényi et al., 1976; Ginsberg et al., 1977; Rehncrona et al., 1979; Siesjö, 1981; Dóra, 1985b/.

Keywords

Middle Cerebral Artery Brain Cortex Sham Control Ischemic Brain Damage Stroke Group 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Eörs Dóra
    • 1
  • Joel H. Greenberg
    • 1
  • Kortaro Tanaka
    • 1
  • Nicholas H. Gonatas
    • 1
  • Martin Reivich
    • 1
  1. 1.Cerebrovascular Research Center, Department of NeurologyUniversity of PennsylvaniaPhiladelphiaUSA

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